Geranylgeraniol Potently Induces Caspase-3-like Activity during Apoptosis in Human Leukemia U937 Cells

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Assay for nanogram quantities of DNA in cellular homogenates

1979 • 923 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Death and the cell

1986 • 616 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Identification of Geranylgeranyl-Modified Proteins in HeLa Cells

1990 • 217 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.

1992 • 158 citations

The Cooperative Interaction of Two Different Signaling Pathways in Response to Bufalin Induces Apoptosis in Human Leukemia U937 Cells

1996 • 136 citations

Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells

1995 • 119 citations

Geranylgeraniol Is a Potent Inducer of Apoptosis in Tumor Cells

1995 • 89 citations

Molecular epidemiology: Low-dose carcinogens and genetic susceptibility

1997 • 76 citations

Topoisomerase Inhibitors Have Potent Differentiation‐inducing Activity for Human and Mouse Myeloid Leukemia Cells

1991 • 52 citations

Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells

1997 • 24 citations

Geranylgeranylacetone Used as an Antiulcer Agent Is a Potent Inducer of Differentiation of Various Human Myeloid Leukemia Cell Lines

1993 • 23 citations

Identification of Histone H2A.X as a Growth Factor Secreted by an Androgen-independent Subline of Mouse Mammary Carcinoma Cells

1996 • 22 citations

Determination of some nuclear deoxyribonucleases in X-irradiated rat thymocytes

1992 • 11 citations