Effects of chronic treatment with escitalopram or citalopram on extracellular 5‐HT in the prefrontal cortex of rats: role of 5‐HT_1A receptors

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

WITHDRAWN: References

1982 • 822 citations

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

1995 • 610 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Functional Neuroimaging Studies of Depression: The Anatomy of Melancholia

1998 • 503 citations

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

2001 • 485 citations

Fixed-Dose Trial of the Single Isomer SSRI Escitalopram in Depressed Outpatients

2002 • 358 citations

Occupancy of Serotonin Transporters by Paroxetine and Citalopram During Treatment of Depression: A [¹¹C]DASB PET Imaging Study

2001 • 336 citations

Effectiveness of Pindolol With Selected Antidepressant Drugs in the Treatment of Major Depression

1995 • 323 citations

Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain

1986 • 323 citations

The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer

1992 • 321 citations

Interaction between a selective 5‐HT_1Areceptor antagonist and an SSRI in vivo: effects on 5‐HT cell firing and extracellular 5‐HT

1995 • 312 citations

Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

1995 • 278 citations

Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex

1992 • 275 citations

Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities

2003 • 264 citations

Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis

1994 • 261 citations

Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei

1993 • 239 citations

Serotonin 5‐HT_1A Autoreceptor Blockade Potentiates the Ability of the 5‐HT Reuptake Inhibitor Citalopram to Increase Nerve Terminal Output of 5‐HT In Vivo: A Microdialysis Study

1993 • 236 citations

Escitalopram 10???mg/day is effective and well tolerated in a placebo-controlled study in depression in primary care

2002 • 236 citations

Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat

1983 • 223 citations

Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex

1991 • 222 citations

Escitalopram (10–20 mg/day) is effective and well tolerated in a placebo-controlled study in depression in primary care

2003 • 220 citations

Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis

1991 • 206 citations

Role of 5‐HT_1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies

1996 • 195 citations

Citalopram

1991 • 193 citations

Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial

1997 • 177 citations

Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171

1977 • 174 citations

The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats

2003 • 168 citations

Paroxetine and pindolol

1997 • 164 citations

How Long Should Pindolol Be Associated With Paroxetine to Improve the Antidepressant Response?

1997 • 157 citations

Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine

1994 • 156 citations

Preferential Potentiation of the Effects of Serotonin Uptake Inhibitors by 5‐HT_1A Receptor Antagonists in the Dorsal Raphe Pathway: Role of Somatodendritic Autoreceptors

1997 • 153 citations

Escitalopram (S-Enantiomer of Citalopram): Clinical Efficacy and Onset of Action Predicted from a Rat Model

2001 • 150 citations

Potentiation of the Fluoxetine‐Induced Increase in Dialysate Levels of Serotonin (5‐HT) in the Frontal Cortex of Freely Moving Rats by Combined Blockade of 5‐HT_1A and 5‐HT_1B Receptors with WAY 100,635 and GR 127,935

1997 • 133 citations

Escitalopram

2003 • 132 citations

Role of 5-HT1A receptors in the effects of acute and chronic fluoxetine on extracellular serotonin in the frontal cortex

1996 • 127 citations

Effect of Pindolol on Onset of Action of Paroxetine in the Treatment of Major Depression: Intermediate Analysis of a Double-Blind, Placebo-Controlled Trial

1998 • 127 citations

Analysis of Enantiomers of Citalopram and Its Demethylated Metabolites in Plasma of Depressive Patients Using Chiral Reverse-Phase Liquid Chromatography

1995 • 126 citations

Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HT1A receptors

1994 • 125 citations

Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans

1997 • 117 citations

Faster Onset of Action of Fluvoxamine in Combination With Pindolol in the Treatment of Delusional Depression

1998 • 111 citations

Desensitization of 5-HT1A Autoreceptors by a Low Chronic Fluoxetine Dose Effect of the Concurrent Administration of WAY-100635

2001 • 111 citations

Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine.

1994 • 107 citations

Effect of 5-HT1A Receptor Antagonists on Citalopram-induced Increase in Extracellular Serotonin in the Frontal Cortex, Striatum and Dorsal Hippocampus

1997 • 102 citations

Role of uptake inhibition and autoreceptor activation in the control of 5‐HT release in the frontal cortex and dorsal hippocampus of the rat

2000 • 102 citations

Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: Single-cell studies in the rat

1984 • 97 citations

Citalopram: a comprehensive review

2001 • 95 citations

The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram

1996 • 93 citations

Fluoxetine Increases Extracellular Dopamine in the Prefrontal Cortex by a Mechanism Not Dependent on Serotonin

1999 • 86 citations

Lack of 5-HT1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis

1994 • 75 citations

Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography

1998 • 73 citations

Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment

1996 • 70 citations

The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders

1993 • 68 citations

Effect of chronic fluoxetine and WAY-100635 treatment on serotonergic neurotransmission in the frontal cortex

2002 • 67 citations

Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo

1995 • 64 citations

Augmentation with a 5-HT1A, but not a 5-HT1B receptor antagonist critically depends on the dose of citalopram

2000 • 64 citations

Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex

1998 • 63 citations

Effects of chronic fluoxetine treatment in the presence and absence of (±)pindolol: a microdialysis study

2000 • 62 citations

Autoreceptor Antagonists Enhance the Effect of the Reuptake Inhibitor Citalopram on Extracellular 5-HT: this Effect Persists After Repeated Citalopram Treatment

1997 • 61 citations

Stereoselective HPLC-Assay for Citalopram and Its Metabolites

2000 • 57 citations

Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptors

1993 • 52 citations

Desensitisation of 5-HT autoreceptors upon pharmacokinetically monitored chronic treatment with citalopram

2000 • 50 citations

Citalopram‐induced hypophagia is enhanced by blockade of 5‐HT_1A receptors: role of 5‐HT_2C receptors

1998 • 46 citations

Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?

1988 • 40 citations

Escitalopram (S‐Enantiomer of Citalopram): Clinical Efficacy and Onset of Action Predicted from a Rat Model

2001 • 38 citations

Subchronic fluoxetine administration to rats: effects on 5-HT autoreceptor activity as measured by in vivo microdialysis

2000 • 18 citations

Repeated but not acute clomipramine decreases the effect of N-methyl-d-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex

2001 • 12 citations