Subchronic fluoxetine administration to rats: effects on 5-HT autoreceptor activity as measured by in vivo microdialysis

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

1995 • 278 citations

Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine

1995 • 257 citations

Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat

1990 • 200 citations

Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive–compulsive disorder responses

1998 • 189 citations

Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain

1988 • 177 citations

Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.

1996 • 162 citations

Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine

1994 • 156 citations

Long-term fluoxetine, but not desipramine, inhibits the ACTH and oxytocin responses to the 5-HT1A agonist, 8-OH-DPAT, in male rats

1993 • 138 citations

Effect of a selective 5‐HT reuptake inhibitor in combination with 5‐HT_1A and 5‐HT_1B receptor antagonists on extracellular 5‐HT in rat frontal cortex in vivo

1997 • 136 citations

Potentiation of the Fluoxetine‐Induced Increase in Dialysate Levels of Serotonin (5‐HT) in the Frontal Cortex of Freely Moving Rats by Combined Blockade of 5‐HT_1A and 5‐HT_1B Receptors with WAY 100,635 and GR 127,935

1997 • 133 citations

Chronic Fluoxetine Reduces Serotonin Transporter mRNA and 5-HT1B mRNA in a Sequential Manner in the Rat Dorsal Raphe Nucleus

1996 • 131 citations

Alteration of Serotonin Release in the Guinea Pig Orbito-Frontal Cortex by Selective Serotonin Reuptake Inhibitors Relevance to Treatment of Obsessive-Compulsive Disorder

1995 • 129 citations

Role of 5-HT1A receptors in the effects of acute and chronic fluoxetine on extracellular serotonin in the frontal cortex

1996 • 127 citations

Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HT1A receptors

1994 • 125 citations

Differential responsiveness of the rat dorsal and median raphe 5‐HT systems to 5‐HT₁ receptor agonists and p‐chloroamphetamine

1990 • 124 citations

Modulation of 5‐HT release in the guinea‐pig brain following long‐term administration of antidepressant drugs

1994 • 120 citations

Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors

1998 • 118 citations

Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder

1991 • 105 citations

The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram

1996 • 93 citations

Combined Administration of a 5‐Hydroxytryptamine (5‐HT)_1D Antagonist and a 5‐HT Reuptake Inhibitor Synergistically Increases 5‐HT Release in Guinea Pig Hypothalamus In Vivo

1996 • 91 citations

5-HT1A Receptor Function in Normal Subjects on Clinical Doses of Fluoxetine Blunted Temperature and Hormone Responses to Ipsapirone Challenge

1999 • 89 citations

Chronic desipramine and fluoxetine differentially affect extracellular dopamine in the rat prefrontal cortex

1996 • 89 citations

Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain

1996 • 82 citations

Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats

1995 • 80 citations

Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat

1995 • 80 citations

Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram

1995 • 76 citations

Chronic clomipramine and triiodothyronine increase serotonin levels in rat frontal cortex in vivo: relationship to serotonin autoreceptor activity.

1999 • 72 citations

Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice

1995 • 69 citations

Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats

1997 • 67 citations

Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats

1994 • 65 citations

Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo

1995 • 64 citations

Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice

1995 • 63 citations

Autoreceptor Antagonists Enhance the Effect of the Reuptake Inhibitor Citalopram on Extracellular 5-HT: this Effect Persists After Repeated Citalopram Treatment

1997 • 61 citations

Effect of paroxetine and nefazodone on 5-HT 1A receptor sensitivity

1997 • 61 citations

Differential effects of 5-HT1B/1D receptor antagonists in dorsal and median raphe innervated brain regions

1998 • 59 citations

Chronic electroconvulsive shock and desimipramine reduce the degree of inhibition by 5-HT and carbachol of forskolin-stimulated adenylate cyclase in rat hippocampal membranes

1988 • 59 citations

Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain.

1990 • 58 citations

Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants.

1992 • 55 citations

In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei

1998 • 51 citations

Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studies using fast cyclic voltammetry in vitro

1994 • 50 citations

Effect of chronic antidepressant treatment on 5-HT1B presynaptic heteroreceptors inhibiting acetylcholine release

1994 • 41 citations

Serotonin 5‐HT_1A Receptor Activation Increases Cyclic AMP Formation in the Rat Hippocampus In Vivo

1994 • 39 citations

Diurnal variation in 5‐HT_1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment

1999 • 37 citations

The effect of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers

1996 • 29 citations

Synergism between 5-HT1B/1D and 5-HT1A receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo

1999 • 26 citations

8-Hydroxy-2-(DI-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats

1991 • 24 citations

Synergism of 5-HT 1B/D Antagonists With Paroxetine on Serotonin Efflux in Rat Ventral Lateral Geniculate Nucleus Slices

1997 • 12 citations

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