Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Evolution of the neuropathology of Alzheimer's disease

1996 • 673 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Cerebral amyloid deposition and diffuse plaques in ``normal'' aging

1996 • 600 citations

Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

1995 • 525 citations

Alzheimer's disease

1998 • 517 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

1996 • 384 citations

Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

1995 • 372 citations

Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

1996 • 340 citations

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

1995 • 207 citations

Progression of Cerebral Amyloid Angiopathy: Accumulation of Amyloid-ß40 in Affected Vessels

1998 • 176 citations

Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder

1994 • 170 citations

Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes

1995 • 166 citations

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.

1998 • 148 citations

Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study.

1990 • 119 citations

Aβ‐peptide length aid apolipoprotein E genotype in Alzheimer's disease

1996 • 119 citations

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.

1991 • 98 citations

Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele

1997 • 92 citations

Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives

1995 • 92 citations

The role of APOE polymorphisms in late-onset dementias

1998 • 89 citations

Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease.

1990 • 79 citations

A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles

1989 • 72 citations

Apolipoprotein E allele ε4 is linked to increased deposition of the amyloid β-peptide (A-β) in cases with or without Alzheimer's disease

1994 • 70 citations

Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

1991 • 68 citations

Apolipoprotein E4 Promotes Incipient Alzheimer Pathology in the Elderly

1998 • 68 citations

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

1992 • 67 citations

Apolipoprotein E and Alzheimer's Disease: A Review of Recent Studies

1997 • 61 citations

Apolipoprotein E Genotype and Deposits of Aβ40 and Aβ42 in Alzheimer Disease

1998 • 58 citations

Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.

1993 • 46 citations

Amyloid β protein (Aβ) deposition in dementia with Lewy bodies: predominance of Aβ₄₂₍₄₃₎ and paucity of Aβ₄₀ compared with sporadic Alzheimer’s disease

1998 • 31 citations

Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for A beta 40 and the A beta that ends at residues alanine42/threonine43 (A beta 42).

1997 • 29 citations

Associations of Status and Change Measures of Neuropsychological Function With Pathologic Changes in Elderly, Originally Nondemented Subjects

1996 • 24 citations

The relationship between tangle and plaque formation during healthy aging and mild dementia

1993 • 22 citations

A modified method for the detection of nucleolar organizer regions (AgNORs)

1991 • 17 citations

Characterization of amyloid β protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay

1997 • 17 citations

Non-Alzheimer neurofibrillary tangles show β-amyloid-like immunoreactivity

1994 • 15 citations

Alzheimer's paired helical filaments: Amyloid precursor protein epitope mapping

1994 • 7 citations

Association of cholinesterases with amyloid in extracellular neurofibrillary tangles

1997 • 4 citations