Rational protein design: Combining theory and experiment

Dominant forces in protein folding

1990 • 3,682 citations

Principles of protein folding — A perspective from simple exact models

1995 • 1,532 citations

A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants

1993 • 1,456 citations

Protein Design by Binary Patterning of Polar and Nonpolar Amino Acids

1993 • 737 citations

The dead-end elimination theorem and its use in protein side-chain positioning

1992 • 698 citations

Protein Design: A Hierarchic Approach

1995 • 532 citations

De Novo Design, Expression, and Characterization of Felix: a Four-Helix Bundle Protein of Native-Like Sequence

1990 • 392 citations

De novo design of the hydrophobic cores of proteins

1995 • 301 citations

A test of lattice protein folding algorithms.

1995 • 294 citations

Protein design automation

1996 • 291 citations

Probing the role of packing specificity in protein design

1997 • 252 citations

Construction of new ligand binding sites in proteins of known structure

1991 • 233 citations

Automated design of the surface positions of protein helices

1997 • 233 citations

Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides

1993 • 232 citations

De novo design of the hydrophobic core of ubiquitin

1997 • 181 citations

Protein alchemy: Changing β-sheet into α-helix

1997 • 174 citations

Molecular technology: Designing proteins and peptides

1983 • 164 citations

Sequence space, folding and protein design

1996 • 157 citations

Repacking protein cores with backbone freedom: structure prediction for coiled coils.

1995 • 149 citations

Betadoublet: de novo design, synthesis, and characterization of a beta-sandwich protein.

1994 • 144 citations

Binary patterning of polar and nonpolar amino acids in the sequences and structures of native proteins

1995 • 130 citations

Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme

1992 • 130 citations

Construction of new ligand binding sites in proteins of known structure

1991 • 127 citations

Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992.

1992 • 114 citations

Construction of a catalytically active iron superoxide dismutase by rational protein design

1997 • 113 citations

Protein Design: The Choice of de Novo Sequences

1997 • 104 citations

Coupling backbone flexibility and amino acid sequence selection in protein design

1997 • 91 citations

Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992

1992 • 80 citations

Computational method for the design of enzymes with altered substrate specificity

1991 • 73 citations

Metal search: A computer program that helps design tetrahedral metal‐binding sites

1995 • 52 citations

Metalloprotein design

1996 • 42 citations