MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage

DNA Repair and Mutagenesis

2006 • 4,725 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast

1991 • 1,369 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 • 750 citations

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

1995 • 632 citations

When Checkpoints Fail

1997 • 622 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

1996 • 593 citations

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1997 • 525 citations

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

1994 • 502 citations

Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest

1995 • 418 citations

The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.

1992 • 414 citations

DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint

1995 • 411 citations

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

1998 • 392 citations

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

1995 • 386 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

Methods in enzymology vol 194 guide to yeast genetics and molecular biology

1991 • 359 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

DUN1 encodes a protein kinase that controls the DNA damage response in yeast

1993 • 343 citations

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways.

1996 • 307 citations

Cell cycle checkpoints

1994 • 284 citations

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.

1993 • 263 citations

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1

1997 • 247 citations

Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.

1990 • 223 citations

An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

1994 • 215 citations

Checkpoint Pathways Come of Age

1997 • 204 citations

RAD9, RAD17, and RAD24 Are Required for S Phase Regulation in Saccharomyces cerevisiae in Response to DNA Damage

1997 • 198 citations

RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.

1993 • 195 citations

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1996 • 187 citations

RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.

1996 • 168 citations

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1997 • 160 citations

Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 andCLN2 transcription occur in response to DNA damage inSaccharomyces cerevisiae

1997 • 155 citations

Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.

1994 • 148 citations

The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

1997 • 147 citations

Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage.

1989 • 134 citations

Complete transposition requires four active monomers in the mu transposase tetramer.

1994 • 125 citations

A role for DNA primase in coupling DNA replication to DNA damage response

1997 • 119 citations

A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.

1996 • 111 citations

Rfc5, a Replication Factor C Component, Is Required for Regulation of Rad53 Protein Kinase in the Yeast Checkpoint Pathway

1997 • 91 citations

Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway

1997 • 82 citations

Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.

1996 • 81 citations

The recognition of DNA damage

1996 • 81 citations

Yeast pip3/mec3 Mutants Fail To Delay Entry into S Phase and To Slow DNA Replication in Response to DNA Damage, and They Define a Functional Link between Mec3 and DNA Primase

1996 • 79 citations

From DNA damage to cell cycle arrest and suicide: a budding yeast perspective

1996 • 65 citations

S-phase and DNA-damage checkpoints: a tale of two yeasts

1996 • 39 citations