Scaffolds for engineering novel binding sites in proteins

Naturally occurring antibodies devoid of light chains

1993 • 2,872 citations

Stability of Protein Structure and Hydrophobic Interaction

1988 • 1,293 citations

Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain

1997 • 630 citations

Use of Peptide Libraries to Map the Substrate Specificity of a Peptide-Modifying Enzyme: A 13 Residue Consensus Peptide Specifies Biotinylation in Escherichia coli

1993 • 586 citations

Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme

1996 • 490 citations

Phage Libraries Displaying Cyclic Peptides with Different Ring Sizes: Ligand Specificities of the RGD-Directed Integrins

1995 • 472 citations

Substrate Phage: Selection of Protease Substrates by Monovalent Phage Display

1993 • 337 citations

Selecting high-affinity binding proteins by monovalent phage display

1991 • 312 citations

Isolation of High-affinity Monomeric Human Anti-c-erbB-2 Single chain Fv Using Affinity-driven Selection

1996 • 295 citations

Minimizing a binding domain from protein A.

1996 • 289 citations

A combinatorial library of an α-helical bacterial receptor domain

1995 • 272 citations

Expression of Thioredoxin Random Peptide Libraries on the Escherichia coli Cell Surface as Functional Fusions to Flagellin: A System Designed for Exploring Protein-Protein Interactions

1995 • 254 citations

Scorpion toxins as natural scaffolds for protein engineering.

1995 • 152 citations

Antibody VH Domains as Small Recognition Units

1995 • 137 citations

Constrained peptides as binding entities

1995 • 121 citations

Selection of biologically active peptides by phage display of random peptide libraries

1996 • 120 citations

Identification of biologically active peptides using random libraries displayed on phage

1995 • 119 citations

The role of turns in the structure of an α-helical protein

1993 • 101 citations

Identifying Substrate Motifs of Protein Kinases by a Random Library Approach

1994 • 101 citations

A review of the utility of soluble peptide combinatorial libraries

1995 • 93 citations

Iterative Optimization of High-Affinity Protease Inhibitors Using Phage Display. 1. Plasmin

1996 • 91 citations

Iterative Optimization of High-Affinity Protease Inhibitors Using Phage Display. 2. Plasma Kallikrein and Thrombin

1996 • 89 citations

Tendamistat as a Scaffold for Conformationally Constrained Phage Peptide Libraries

1995 • 84 citations

A Conformationally Homogeneous Combinatorial Peptide Library

1995 • 74 citations

Alternate protein frameworks for molecular recognition.

1995 • 71 citations

Selection of Chymotrypsin Inhibitors from a Conformationally-constrained Combinatorial Peptide Library

1996 • 71 citations

Designing DNA-binding proteins on the surface of filamentous phage

1995 • 69 citations

Isolation of a High Affinity Inhibitor of Urokinase-type Plasminogen Activator by Phage Display of Ecotin

1995 • 69 citations

Production of an atrial natriuretic peptide variant that is specific for type A receptor.

1994 • 68 citations

The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6.

1994 • 64 citations

Affinity purification of von Willebrand factor using ligands derived from peptide libraries

1996 • 58 citations

A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage.

1996 • 58 citations

Coupling Protein Design andin VitroSelection Strategies: Improving Specificity and Affinity of a Designed β-protein IL-6 Antagonist

1996 • 51 citations

Functionalized Protein-like Structures from Conformationally Defined Synthetic Combinatorial Libraries

1996 • 51 citations

A human pancreatic secretory trypsin inhibitor presenting a hypervariable highly constrained epitope via monovalent phagemid display

1995 • 45 citations

Affinity Selective Isolation of Ligands from Peptide Libraries Through Display on alacRepressor "Headpiece Dimer">

1996 • 43 citations

Use of a Conformationally Restricted Secondary Structural Element to Display Peptide Libraries: A Two-stranded α-Helical Coiled-coil Stabilized by Lactam Bridges

1996 • 36 citations

Construction and screening of M13 phage libraries displaying long random peptides

1996 • 31 citations

The making of the minibody: An engineered β‐protein for the display of conformationally constrained peptides

1994 • 29 citations

A combinatorial method for constructing libraries of long peptides displayed by filamentous phage

1995 • 14 citations

The coiled coil stem loop miniprotein as a presentation scaffold.

1996 • 13 citations