Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

1979 • 667 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1980 • 236 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

1979 • 218 citations

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1979 • 110 citations

Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.

1985 • 103 citations

Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia

1977 • 89 citations

Inhibition of in vitro cholesterol synthesis by fatty acids

1977 • 88 citations

Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis.

1985 • 82 citations

Hypolipidemic effects in monkeys of ML‐236B, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

1979 • 81 citations

Monacolin M, a new inhibitor of cholesterol biosynthesis.

1986 • 80 citations

The synthesis of compactin (ML-236B) and monacolin K in fungi.

1986 • 63 citations

Kinetic Analysis of the Reaction Catalyzed by Rat‐Liver 3‐Hydroxy‐3‐methylglutaryl‐coenzyme‐A Reductase Using Two Specific Inhibitors

1979 • 61 citations

Biosynthesis of ML-236B (compactin) and monacolin K.

1985 • 43 citations

Microbial phosphorylation of compactin (ML-236B) and related compounds.

1985 • 24 citations

Microbial hydroxylation of compactin (ML-236B) and monacolin K.

1985 • 23 citations

SPECIFIC INHIBITION OF DESMOSTEROL SYNTHESIS BY ML-236B IN MOUSE LM CELLS GROWN IN SUSPENSION IN A LIPID-FREE MEDIUM

1978 • 17 citations

Microbial conversion of compactin (ML-236B) to ML-236A.

1986 • 14 citations

Regulation of Cholesterol Synthesis in Cultured Mouse Mammary Carcinoma FM3A Cells1

1985 • 8 citations

Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin (ML-236B)-resistant mouse cell line with defects in the regulation of its activity

1987 • 6 citations