Antihistamines in asthma

Bronchial reactivity to inhaled histamine: a method and clinical survey

1977 • 1,884 citations

THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSA

1960 • 1,014 citations

Allergen‐induced increase in non‐allergic bronchial reactivity

1977 • 883 citations

Inflammatory Mediators in Late Antigen-Induced Rhinitis

1985 • 708 citations

The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.

1984 • 664 citations

Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine*1

1987 • 497 citations

Disodium Cromoglycate (FPL 670) (‘Intal’*): a Specific Inhibitor of Reaginic Antibody–Antigen Mechanisms

1967 • 440 citations

Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.

1981 • 409 citations

Eosinophils, bronchial hyperreactivity and late‐phase asthmatic reactions

1985 • 348 citations

Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation.

1987 • 321 citations

The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men

1984 • 319 citations

Generation of leukotrienes by purified human lung mast cells.

1982 • 302 citations

Neutrophil Chemotactic Activity in Antigen-Induced Late Asthmatic Reactions

1982 • 293 citations

Bronchoalveolar Lavage of Allergic Asthmatic Patients following Allergen Bronchoprovocation

1986 • 284 citations

Is there a unifying hypothesis for exercise-induced asthma?

1984 • 280 citations

Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma

1979 • 279 citations

Human skin mast cells: their dispersion, purification, and secretory characterization.

1987 • 274 citations

Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction.

1985 • 254 citations

Inhibition of IgE‐dependent histamine release from human dispersed lung mast cells by anti‐allergic drugs and salbutamol

1987 • 252 citations

Early and Late-Phase Bronchoconstriction After Allergen Challenge of Nonanesthetized Guinea Pigs: I. The Association of Disordered Airway Physiology to Leukocyte Infiltration

1988 • 251 citations

Postexertional airway rewarming and thermally induced asthma. New insights into pathophysiology and possible pathogenesis.

1986 • 242 citations

Late bronchial obstructive reaction to experimental inhalation of house dust extract

1972 • 233 citations

Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma.

1985 • 201 citations

Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics

1982 • 194 citations

Mast cells in bronchoalveolar lumen of patients with bronchial asthma.

1984 • 188 citations

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

1982 • 188 citations

Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells.

1984 • 187 citations

Effect of Disodium Cromoglycate on Exercise-induced Asthma

1968 • 169 citations

Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release.

1984 • 168 citations

Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor.

1988 • 159 citations

Evaluation of Role Played by Mediators of Immediate Hypersensitivity in Exercise-induced Asthma

1980 • 141 citations

Hyperosmolar Triggering of Histamine Release from Human Basophils

1981 • 140 citations

Immunologic studies in allergen-induced late-phase asthmatic reactions

1984 • 140 citations

Hyperosmolarity as the stimulus to asthma induced by hyperventilation?

1986 • 126 citations

Bronchodilating activity of an H blocker, chlorpheniramine

1977 • 123 citations

Venous Plasma Histamine in Exercise- and Hyperventilation Induced Asthma in Man

1981 • 119 citations

The pathogenesis and significance of bronchial hyper-responsiveness in airways disease

1987 • 116 citations

Dispersed human lung mast cells. Pharmacologic aspects and comparison with human lung tissue fragments.

1982 • 115 citations

The mast cell as a primary effector cell in the pathegenesis of asthma

1986 • 111 citations

Terfenadine in exercise induced asthma.

1984 • 109 citations

Specific antagonism of adenosine‐induced bronchoconstriction in asthma by oral theophylline.

1985 • 108 citations

Terfenadine (Seldane) is a potent and selective histamine H1 receptor antagonist in asthmatic airways.

1987 • 99 citations

9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways.

1987 • 97 citations

Airway neuropeptides and asthma

1987 • 91 citations

Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.

1987 • 90 citations

Respiratory symptoms and bronchial reactivity: identification of a syndrome and its relation to asthma.

1986 • 87 citations

Effect of oral terfenadine on the bronchoconstrictor response to inhaled histamine and adenosine 5'-monophosphate in non-atopic asthma.

1987 • 87 citations

Mediator Release in an Isolated Airway Segment in Subjects with Asthma

1988 • 87 citations

Antihistamines in Bronchial Asthma

1949 • 82 citations

Treatment of bronchial asthma with terfenadine; a randomized controlled trial.

1987 • 75 citations

Mast cells in severely T-cell depleted rats and the response to infestation with Nippostrongylus brasiliensis.

1979 • 70 citations

Pathogenesis of asthma

1984 • 70 citations

A dose-response study of the bronchodilator action of azelastine in asthma

1987 • 68 citations

Relationship between Mediator Release from Human Lung Mast Cells in vitro and in vivo

1985 • 67 citations

Mediators in exercise-induced asthma

1984 • 63 citations

Inhaled antihistamines--bronchodilatation and effects on histamine- and methacholine-induced bronchoconstriction.

1978 • 59 citations

The use of antihistamines in asthma.

1972 • 57 citations

HISTAMINE INCREASES LUNG PERMEABILITY BY AN H2-RECEPTOR MECHANISM

1984 • 56 citations

Exercise and isocapnic hyperventilation-induced bronchoconstriction in asthma: Relevance of circulating basophils to measurements of plasma histamine

1984 • 51 citations

Effect of terfenadine on methacholine-induced bronchoconstriction in asthma

1987 • 50 citations

THE EFFECT OF ANTIHISTAMINE SUBSTANCES AND OTHER DRUGS ON HISTAMINE BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS 1

1946 • 50 citations

The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma

1987 • 49 citations

Recent Advances in Understanding the Pathogenesis of Asthma and its Clinical Implications

1988 • 49 citations

Airflow-induced bronchoconstriction: role of epithelium and eicosanoid mediators

1987 • 47 citations

Cholinergic-Mediated Bronchoconstriction Induced by Prostaglandin D₂, Its Initial Metabolite 9α, 11β-PGF₂, and PGF_2αin Asthma

1987 • 43 citations

The role of histamine and its receptors in the pathogenesis of asthma

1983 • 43 citations

The major enzymes of human mast cell secretory granules.

1987 • 42 citations

A comparison of the actions of H and H antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients

1981 • 38 citations

The influence of ipratropium bromide and sodium cromoglycate on benzalkonium chloride‐induced bronchoconstriction in asthma.

1988 • 37 citations

Effect of antihistamines and antiallergic drugs on responses to allergen and histamine provocation tests in asthma.

1984 • 36 citations

Prostaglandin D₂ release from human skin mast cells in response to ionophore A23187

1987 • 36 citations

251 Azelastine (azel) in the treatment of asthma

1985 • 34 citations

Histamine and immune modulation.

1983 • 33 citations

248 Astemizole, a H-antagonist, in allergic asthma

1985 • 32 citations

Modulation of the release of histamine and arachidonic acid metabolites from human basophils and mast cells by auranofin

1986 • 31 citations

H2 antihistamines augment antigen-induced histamine release from human basophils in vitro.

1982 • 28 citations

The bronchodilator effects of chlorpheniramine in childhood asthma

1979 • 27 citations

Histamine in late asthmatic reactions following house-dust mite inhalation

1985 • 26 citations

Cetirizine inhibition of histamine-induced bronchospasm.

1987 • 26 citations

The role of basophils in asthma

1982 • 24 citations

Some properties of mast cells obtained by human bronchoalveolar lavage

1986 • 18 citations

Histamine receptors and pulmonary epithelial permeability

1987 • 18 citations

Mast Cell Heterogeneity

1987 • 11 citations

Mechanisms and significance of adenosine‐induced bronchoconstriction in asthma

1987 • 11 citations

Steroid-sparing effect of ketotifen in steroid-dependent asthmatics: a long period evaluation in 12 patients.

1988 • 7 citations

290 Role of histamine and prostaglandins in EIA

1988 • 4 citations

Some Functional Properties of Human Bronchoalveolar and Dispersed Lung Mast Cells

1987 • 2 citations

515 Mediator release from human skin mast cells activated by IgE-dependent and non-immunological stimuli

1988 • 1 citations