Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expression

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

A Draft Sequence of the Rice Genome ( Oryza sativa L. ssp. indica )

2002 • 4,221 citations

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

2001 • 4,058 citations

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

2000 • 3,871 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

High density synthetic oligonucleotide arrays

1999 • 2,256 citations

Microarray data normalization and transformation

2002 • 1,956 citations

A draft sequence of the rice genome (Oryza sativa L. ssp. indica) : The rice genome

2002 • 1,824 citations

Expression profiling using cDNA microarrays

1999 • 1,689 citations

Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.

1996 • 1,629 citations

Computational analysis of microarray data

2001 • 1,502 citations

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

2001 • 1,297 citations

Fundamentals of experimental design for cDNA microarrays

2002 • 1,070 citations

Protein microarrays and proteomics

2002 • 852 citations

Design issues for cDNA microarray experiments

2002 • 795 citations

Microarray-based detection and genotyping of viral pathogens

2002 • 792 citations

Alternative pre-mRNA splicing and proteome expansion in metazoans

2002 • 755 citations

Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array

1999 • 725 citations

Experimental design for gene expression microarrays

2001 • 709 citations

Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.

2002 • 656 citations

Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays

2000 • 626 citations

Protein microarray technology

2002 • 573 citations

Clinical proteomics: translating benchside promise into bedside reality

2002 • 555 citations

Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays

2002 • 522 citations

Analysis of matched mRNA measurements from two different microarray technologies

2002 • 486 citations

Gene Expression Analysis Reveals Chemical-Specific Profiles

2002 • 435 citations

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

2002 • 406 citations

Gene Expression Analysis Using Oligonucleotide Arrays Produced by Maskless Photolithography

2002 • 356 citations

High-density oligonucleotide arrays

1996 • 328 citations

A perspective on protein microarrays

2002 • 314 citations

Statistical issues with microarrays: processing and analysis

2002 • 297 citations

Multi-analyte immunoassay

1989 • 292 citations

Optimization of oligonucleotide-based DNA microarrays

2002 • 289 citations

Microarray results: how accurate are they?

2002 • 286 citations

DNA Microarrays of the Complex Human Cytomegalovirus Genome: Profiling Kinetic Class with Drug Sensitivity of Viral Gene Expression

1999 • 258 citations

Options available—from start to finish—for obtaining data from DNA microarrays II

2002 • 256 citations

Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range

2002 • 255 citations

Selection of optimal DNA oligos for gene expression arrays

2001 • 229 citations

Medical applications of microarray technologies: a regulatory science perspective

2002 • 227 citations

Quantitative Assessment of DNA Microarrays—Comparison with Northern Blot Analyses

2001 • 217 citations

Design of studies using DNA microarrays

2002 • 196 citations

Toxicogenomics and drug discovery: will new technologies help us produce better drugs?

2002 • 187 citations

Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential22Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; Cy, Cyanine; DLCL, diffuse large cell lymphoma; dNTPs, deoxyribonucleotides; ESTs, expressed sequence tags; mRNA, messenger RNA; NHL, non-Hodgkin’s lymphoma; ORF, open reading frame; RT-PCR, reverse transcription-polymerase chain reaction; and 17AAG, 17-allylamino,17-demethoxygeldanamycin.

2001 • 185 citations

OligoArray: genome-scale oligonucleotide design for microarrays

2002 • 161 citations

Microarray databases: standards and ontologies

2002 • 160 citations

Global Analysis of Herpes Simplex Virus Type 1 Transcription Using an Oligonucleotide-Based DNA Microarray

2000 • 147 citations

Better therapeutics through microarrays

2002 • 144 citations

Strategies in the Preparation of DNA Oligonucleotide Arrays for Diagnostic Applications

2001 • 140 citations

Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples

2002 • 129 citations

Differential Gene Expression Patterns Revealed by Oligonucleotide Versus Long cDNA Arrays

2002 • 125 citations

Systematic Management and Analysis of Yeast Gene Expression Data

2000 • 120 citations

Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis*

2002 • 115 citations

High specific activity chemiluminescent and fluorescent markers: Their potential application to high sensitivity and ‘multi‐analyte’ immunoassays

1989 • 64 citations

Serial Analysis of Gene Expression

2002 • 64 citations

The dynamics of molecular networks: applications to therapeutic discovery

2001 • 60 citations

[1] Fluorescence-based expression monitoring using microarrays

1999 • 48 citations

General and Specific Alterations in Programming of Global Viral Gene Expression during Infection by VP16 Activation-Deficient Mutants of Herpes Simplex Virus Type 1

2002 • 39 citations

Microarray Data Representation, Annotation and Storage

2002 • 32 citations

Practical approaches to long oligonucleotide-based DNA microarray: Lessons from herpesviruses

2002 • 28 citations

Oliz, a suite of Perl scripts that assist in the design of microarrays using 50mer oligonucleotides from the 3' untranslated region

2002 • 27 citations

Biological lithography: development of a maskless microarray synthesizer for DNA chips

2002 • 24 citations

Long Oligonucleotide Arrays on Nylon for Large-Scale Gene Expression Analysis

2002 • 23 citations

Perspective: How to Make Microarray, Serial Analysis of Gene Expression, and Proteomic Relevant to Day-to-Day Endocrine Problems and Physiological Systems

2002 • 14 citations

Expression Monitoring Using cDNA Microarrays: A General Protocol

2003 • 11 citations

Probing the proteome – protein arrays and their applications

2001 • 5 citations

RT-PCR in Biomedicine: Opportunities Arising from the New Accessibility of mRNA

2003 • 3 citations

Perspective: How to Make Microarray, Serial Analysis of Gene Expression, and Proteomic Relevant to Day-to-Day Endocrine Problems and Physiological Systems

2002 • 2 citations