Spatial Relational Memory Requires Hippocampal Adult Neurogenesis

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

The Hippocampus as a Cognitive Map

1979 • 1,966 citations

A cortical–hippocampal system for declarative memory

2000 • 1,668 citations

Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

2007 • 1,550 citations

Milestones of neuronal development in the adult hippocampus

2004 • 1,389 citations

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

2004 • 1,256 citations

Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus

2000 • 1,022 citations

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

2006 • 992 citations

Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia

1989 • 963 citations

Adult Neurogenesis: From Precursors to Network and Physiology

2005 • 961 citations

Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

2007 • 928 citations

Neurogenesis may relate to some but not all types of hippocampal‐dependent learning

2002 • 854 citations

Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus

2007 • 854 citations

Quantitative Fluorescence Resonance Energy Transfer Measurements Using Fluorescence Microscopy

1998 • 841 citations

A role for adult neurogenesis in spatial long-term memory

2004 • 830 citations

Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation

1996 • 789 citations

Hippocampal representation in place learning

1990 • 778 citations

The hippocampal memory indexing theory.

1986 • 692 citations

The hippocampal memory indexing theory.

1986 • 682 citations

Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis

2004 • 670 citations

Comparison between the behavioural effects of septal and hippocampal lesions: A review

1983 • 666 citations

Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

2004 • 638 citations

Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis

2003 • 638 citations

Potential role for adult neurogenesis in the encoding of time in new memories

2006 • 631 citations

Fluoxetine targets early progenitor cells in the adult brain

2006 • 612 citations

A computational theory of hippocampal function, and empirical tests of the theory

2006 • 591 citations

Inhibition of neurogenesis interferes with hippocampus‐dependent memory function

2006 • 573 citations

GFAP promoter-controlled EGFP-expressing transgenic mice: A tool to visualize astrocytes and astrogliosis in living brain tissue

2001 • 534 citations

Is there a link between adult neurogenesis and learning?

2006 • 529 citations

Reversible neural inactivation reveals hippocampal participation in several memory processes

1999 • 483 citations

Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis

2007 • 483 citations

Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat

2003 • 476 citations

A theory of hippocampal function in memory

1996 • 474 citations

Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

2006 • 449 citations

New life in an old idea: The synaptic plasticity and memory hypothesis revisited

2002 • 420 citations

Heterogenous properties of dentate granule neurons in the adult rat

2000 • 415 citations

Gradual Changes in Hippocampal Activity Support Remembering the Order of Events

2007 • 396 citations

Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons

2007 • 394 citations

Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

2006 • 364 citations

Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus

2006 • 352 citations

The use of FRET imaging microscopy to detect protein–protein interactions and protein conformational changes in vivo

2001 • 342 citations

Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis

2006 • 317 citations

Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning

2004 • 309 citations

Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus

2006 • 284 citations

Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory

2006 • 275 citations

The permeability transition pore signals apoptosis by directing Bax translocation and multimerization

2002 • 255 citations

A computational principle for hippocampal learning and neurogenesis

2005 • 245 citations

Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date

2003 • 241 citations

Place navigation by rats in a swimming pool.

1984 • 220 citations

Temporally Specific Burst in Cell Proliferation Increases Hippocampal Neurogenesis in Protracted Abstinence from Alcohol

2004 • 219 citations

Sleep Restriction Suppresses Neurogenesis Induced by Hippocampus-Dependent Learning

2005 • 214 citations

Spatial learning affects immature granule cell survival in adult rat dentate gyrus

2000 • 205 citations

A behavioral analysis of dentate gyrus function

2007 • 205 citations

Lifelong corticosterone level determines age-related decline in neurogenesis and memory

2005 • 196 citations

Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax

2004 • 191 citations

Dentate gyrus-selective colchicine lesion and disruption of performance in spatial tasks: Difficulties in ?place strategy? because of a lack of flexibility in the use of environmental cues?

1999 • 174 citations

Retrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after reminding

2004 • 152 citations

Visits to starts, routes, and places by rats (Rattus norvegicus) in swimming pool navigation tasks.

1986 • 149 citations

Cognitive Performances and Locomotor Activity Following Dentate Granule Cell Damage in Rats: Role of Lesion Extent and Type of Memory Tested

2001 • 140 citations

Episodic memory and cortico–hippocampal interactions

2002 • 137 citations

Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests

2006 • 135 citations

Impaired remote spatial memory after hippocampal lesions despite extensive training beginning early in life

2005 • 129 citations

A comparison and evaluation of the predictions of relational and conjunctive accounts of hippocampal function

2005 • 128 citations

Overexpression of Low Density Lipoprotein (LDL) Receptor Eliminates LDL from Plasma in Transgenic Mice

1988 • 121 citations

Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats

2007 • 116 citations

Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation

2007 • 114 citations

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

2015 • 108 citations

Visits to starts, routes, and places by rats (Rattus norvegicus) in swimming pool navigation tasks.

1986 • 108 citations

The Proapoptotic Activities of Bax and Bak Limit the Size of the Neural Stem Cell Pool

2003 • 107 citations

Irradiation as an experimental tool in studies of adult neurogenesis

2006 • 104 citations

Adult Neurogenesis and Hippocampal Memory Function: New Cells, More Plasticity, New Memories?

2007 • 98 citations

Overexpression of p27 ^Kip1 lengthens the G ₁ phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells

2001 • 98 citations

Differential Modulation of Changes in Hippocampal–Septal Synaptic Excitability by the Amygdala as a Function of Either Elemental or Contextual Fear Conditioning in Mice

1998 • 79 citations

Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus

2005 • 72 citations

Involvement of microtubule integrity in memory impairment caused by colchicine

2002 • 70 citations

The dentate gyrus : a comprehensive guide to structure, function, and clinical implications

2007 • 65 citations

Increase of striatal methionin enkephalin content following lesion of the nigrostriatal dopaminergic pathway in adult rats and reversal following the implantation of embryonic dopaminergic neurons: A quantitative immunohistochemical analysis

1991 • 55 citations

Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components

1989 • 53 citations

The effects of ibotenic hippocampal lesions on discriminative fear conditioning to context in mice: impairment or facilitation depending on the associative value of a phasic explicit cue

2003 • 42 citations

21 Neurogenesis and Hippocampal Memory System

2008 • 17 citations