Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

International Union of Pharmacology. XIII. Classification of histamine receptors.

1997 • 869 citations

Cloning and Functional Expression of the Human Histamine H₃Receptor

1999 • 710 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes

2000 • 609 citations

Torsades de pointes occurring in association with terfenadine use

1990 • 550 citations

Cloning and characterization of a novel human histamine receptor.

2001 • 277 citations

Receptor‐activated calcium influx in human airway smooth muscle cells.

1991 • 258 citations

Histamine H₁-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gα_q/11-Subunits in Constitutive and Agonist-Mediated Signaling

2001 • 253 citations

Second-Generation Antihistamines

1999 • 238 citations

Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

1991 • 230 citations

Molecular cloning of the human histamine H2 receptor

1991 • 183 citations

Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

2000 • 162 citations

Torsade de pointes after astemizole overdose.

1986 • 157 citations

Genomic Cloning, Heterologous Expression and Pharmacological Characterization of a Human Histamine H1 Receptor

1993 • 131 citations

Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor

1999 • 118 citations

Histamine-induced calcium release and phorbol antagonism in cultured airway smooth muscle cells

1987 • 115 citations

Preclinical Pharmacology of Desloratadine, a Selective and Nonsedating Histamine H1 Receptor Antagonist

2011 • 106 citations

Mechanism of the cardiotoxic actions of terfenadine

1993 • 93 citations

The assessment of antagonist potency under conditions of transient response kinetics

1999 • 65 citations

Functional studies but not receptor binding can distinguish surmountable from insurmountable AT1 antagonism.

1995 • 55 citations

Stable Expression of Human H₁‐histamine‐receptor cDNA in Chinese Hamster Ovary Cells

1994 • 53 citations

Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study

1993 • 44 citations

Analysis of Apparent Noncompetitive Responses to Competitive H1-Histamine Receptor Antagonists in Fluorescent Imaging Plate Reader-Based Calcium Assays

1999 • 40 citations

Histamine-induced calcium mobilization in single cultured cells expressing histamine H1 receptors: a relationship between its sensitivity and the density of H1 receptors.

1998 • 28 citations

Prolonged QT interval and torsade de pointes following astemizole overdose

1993 • 23 citations

Pharmacological treatment options for allergic rhinitis and asthma.

1998 • 23 citations

Temperature‐dependence of the kinetics of the binding of [₃H]‐(+)‐N‐methyl‐4‐methyldiphenhydramine to the histamine H₁‐receptor: comparison with the kinetics of [₃H]‐mepyramine

1988 • 19 citations

Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist

1997 • 12 citations

1123 Efficacy and safety of desloratadine in seasonal allergic rhinitis

2000 • 12 citations

1120 Preclinical cardiovascular and CNS safety profile of desloratadine, a selective and nonsedating histamine H1-receptor antagonist

2000 • 4 citations

Advancement of the Third Generation of Antihistamines

1999 • 3 citations