The assessment of antagonist potency under conditions of transient response kinetics

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Muscarinic Receptors—Characterization, coupling and function

1993 • 1,264 citations

Operational models of pharmacological agonism

1983 • 1,062 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

The margin of safety of neuromuscular transmission

1967 • 409 citations

Pharmacologic analysis of drug-receptor interaction

1995 • 255 citations

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁‐receptor subtype

1993 • 254 citations

pA_x AND COMPETITIVE DRUG ANTAGONISM

1949 • 247 citations

Assessing the distribution of parameters in models of ligand–receptor interaction: to log or not to log

1998 • 174 citations

Muscarinic receptor differentiation

1988 • 158 citations

Analysis of competitive agonist-antagonist interactions by nonlinear regression

1995 • 143 citations

Is prenalterol (H133/80) really a selective beta 1 adrenoceptor agonist? Tissue selectivity resulting from differences in stimulus-response relationships.

1980 • 121 citations

Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model

1994 • 65 citations

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

1992 • 65 citations

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.

1998 • 61 citations

Qualitative and quantitative assessment of relative agonist efficacy

1999 • 55 citations

Unsurmountable antagonism to 5-hydroxytryptamine in rat kidney results from pseudoirreversible inhibition rather than multiple receptors or allosteric receptor modulation.

1989 • 35 citations

Kinetic studies on the interaction of nonlabeled antagonists with the angiotensin II receptor

1995 • 25 citations

Promiscuous or heterogeneous muscarinic receptors in rat atria? I. Schild analysis with simple competitive antagonists

1990 • 22 citations

Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro.

1988 • 21 citations

M₁ Muscarinic Receptors Stimulate Rapid and Prolonged Phases of Neuronal Nitric Oxide Synthase Activity: Involvement of Different Calcium Pools

1998 • 20 citations

Different apparent modes of inhibition of α2A-adrenoceptor by α2-adrenoceptor antagonists

1997 • 19 citations

Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine.

1988 • 18 citations

N, N-Diethy1-2-(1-pyridyl)ethylamine, a partial agonist for the histamine receptor in guinea pig ileum

1980 • 17 citations

Pseudo-Noncompetitive Antagonism of M1, M3, and M5Muscarinic Receptor-Mediated Ca2+Mobilization by Muscarinic Antagonists

1998 • 15 citations

Promiscuous or heterogeneous muscarinic receptors in rat atria? II. Antagonism of responses to carbachol by pirenzepine

1990 • 6 citations

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