Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's Disease neuropathology

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

1999 • 1,488 citations

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

2000 • 880 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases

1997 • 486 citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1998 • 455 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Molecular pathology of cyclooxygenase-2 in neoplasia.

2000 • 406 citations

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

1997 • 396 citations

Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex

2000 • 253 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease

1999 • 243 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

1999 • 237 citations

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.

2000 • 235 citations

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

1999 • 220 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Neuronal Cyclooxygenase 2 Expression in the Hippocampal Formation as a Function of the Clinical Progression of Alzheimer Disease

2001 • 200 citations

Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus

1999 • 195 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Discussion

1998 • 161 citations

Cyclin' toward dementia

2000 • 158 citations

Abortive apoptosis in Alzheimer's disease

2001 • 157 citations

Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment

2000 • 143 citations

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures

1996 • 136 citations

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease

1999 • 128 citations

Regional Expression and Role of Cyclooxygenase-2 Following Experimental Traumatic Brain Injury

2000 • 125 citations

Cell cycle-related protein expression in vascular dementia and Alzheimer's disease

1999 • 95 citations

Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: Platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression

1999 • 94 citations

Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death

1998 • 67 citations

E2F-Rb Complexes Assemble and Inhibit cdc25A Transcription in Cervical Carcinoma Cells following Repression of Human Papillomavirus Oncogene Expression

2000 • 52 citations

Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

1998 • 45 citations

Epidemiologic clues to the causes and routes to prevention of Alzheimer disease

2000 • 9 citations

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