Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

1997 • 728 citations

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.

1996 • 597 citations

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

1998 • 343 citations

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N -methyl- <scp>d</scp> -aspartic acid-receptors and phospholipase A ₂

1997 • 286 citations

Kainic acid-induced seizures: Dose-relationship of behavioural neurochemical and histopathological changes

1985 • 215 citations

Cyclooxygenase‐2 Induction in Cerebral Cortex: An Intracellular Response to Synaptic Excitation

1996 • 201 citations

Cyclooxygenase‐2 is induced globally in infarcted human brain

1998 • 193 citations

Maturational Regulation and Regional Induction of Cyclooxygenase-2 in Rat Brain: Implications for Alzheimer's Disease

1997 • 175 citations

Sustained Induction of Prostaglandin Endoperoxide Synthase-2 by Seizures in Hippocampus

1996 • 160 citations

Prostaglandin E2 protects cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity

1994 • 137 citations

Expression of cyclo-oxygenase 2 in rat brain following kainate treatment

1995 • 102 citations

Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain

1982 • 95 citations

Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: interaction with neuronal NOS

1998 • 90 citations

Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord

1997 • 84 citations

DNA Fragmentation and Prolonged Expression of c-fos, c-jun, and hsp70 in Kainic Acid-Induced Neuronal Cell Death in Transgenic Mice Overexpressing Human CuZn-Superoxide Dismutase

1997 • 81 citations

The Selective Prostaglandin Endoperoxide Synthase-2 Inhibitor, NS-398, Reduces Prostaglandin Production and Ovulation In Vivo and In Vitro in the Rat1

1998 • 81 citations

The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity

1994 • 80 citations

Different substrate utilization between prostaglandin endoperoxide H synthase-1 and -2 in NIH3T3 fibroblasts

1998 • 77 citations

Increased prostaglandin formation in rat brain following systemic application of kainic acid

1987 • 66 citations

Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis

1994 • 65 citations

Key role for cyclooxygenase-2 in PGE₂and PGF_2αreceptor regulation and cerebral blood f low of the newborn

1997 • 50 citations

Systemic Administration of Nω-Nitro-l-Arginine Methyl Ester and Indomethacin Reduces the Elevation of Brain PGE2Content and Prevents Seizures and Hippocampal Damage Evoked by LiCl and Tacrine in Rat

1998 • 49 citations

Cyclo‐oxygenase isozymes in mucosal ulcerogenic and functional responses following barrier disruption in rat stomachs

1997 • 42 citations

Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina

1998 • 41 citations

Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2

1998 • 39 citations

Precise location of fast and slow pyramidal tract cells in cat sensorimotor cortex

1969 • 37 citations

Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival?

1997 • 35 citations

Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice

1997 • 32 citations

Peptidergic and cholinergic neurons and mediators in peptone-induced gastroprotection: role of cyclooxygenase-2

1998 • 32 citations

The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats

1996 • 28 citations

Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils

1984 • 26 citations

Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gerbils

1998 • 25 citations

Modulation of Glutamate and Aspartate Release from Slices of Hippocampal Area CA1 by Inhibitors of Arachidonic Acid Metabolism

1995 • 23 citations

The cytoprotective properties of prostaglandin E2 against the toxic effects of actinomycin C on embryonic neural retina cells

1992 • 19 citations