Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Principles of CDK regulation

1995 • 3,267 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Kainic acid seizures in the rat

1994 • 693 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

1982 • 481 citations

Control of apoptosis by the cellular ATP level

1996 • 465 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Replicating Huntington's disease phenotype in experimental animals

1999 • 410 citations

The retinoblastoma gene family in differentiation and development

1999 • 409 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Cell cycle markers in the hippocampus in Alzheimer's disease

1997 • 315 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

Cyclin-dependent kinases as a therapeutic target for stroke

2000 • 276 citations

G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis

1997 • 275 citations

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1997 • 270 citations

Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle.

1998 • 270 citations

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1997 • 266 citations

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

1998 • 264 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons

1996 • 252 citations

Mechanisms of Cell Death Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Acute Excitotoxic Necrosis and Delayed Apoptosis

1997 • 250 citations

Mitotic signaling by β‐amyloid causes neuronal death

1999 • 248 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

Role of Cell Cycle Regulatory Proteins in Cerebellar Granule Neuron Apoptosis

1999 • 238 citations

Autoradiographic localization of high-affinity [3H]kainic acid binding sites in the rat forebrain

1983 • 227 citations

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

1994 • 219 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

Postischemic Administration of AK275, a Calpain Inhibitor, Provides Substantial Protection against Focal Ischemic Brain Damage

1994 • 173 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

MK‐801 Prevents 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinsonism in Primates

1992 • 155 citations

3-Nitropropionic acidʼs lethal triplet

1998 • 151 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1

2000 • 143 citations

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1999 • 141 citations

Nitric Oxide in Neuronal Degeneration

1996 • 140 citations

Excitotoxicity is Required for Induction of Oxidative Stress and Apoptosis in Mouse Striatum by the Mitochondrial Toxin, 3-Nitropropionic Acid

2000 • 118 citations

3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons

1995 • 111 citations

Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade.

1995 • 103 citations

NMDA antagonists partially protect against MPTP induced neurotoxicity in mice

1993 • 90 citations

Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats

1996 • 86 citations

Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.

1991 • 84 citations

Cyclins and their associated cyclin-dependent kinases in the human cell cycle

1993 • 83 citations

Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma Protein

1997 • 80 citations

Immunoreactivity of Cyclin D1/cdk4 in Neurons and Oligodendrocytes After Focal Cerebral Ischemia in Rat

1997 • 76 citations

Autoradiographic visualization of [3H]kainic acid receptor subtypes in the rat hippocampus

1983 • 68 citations

Induction of Cyclin B and H1 Kinase Activity in Apoptotic PC12 Cells

1995 • 64 citations

Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1

1999 • 59 citations

Transgenic mice neuronally expressing baculoviral p35 are resistant to diverse types of induced apoptosis, including seizure-associated neurodegeneration

2000 • 53 citations

Energy and Glutamate Dependency of 3-Nitropropionic Acid Neurotoxicity in Culture

1996 • 52 citations

Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment

1996 • 51 citations

The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase.

1995 • 47 citations

Susceptibility to Cell Death Induced by Mutant SV40 T-Antigen Correlates with Purkinje Neuron Functional Development

1997 • 23 citations