Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites

1974 • 3,603 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION

1979 • 2,730 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Nucleotide sequence of bacteriophage λ DNA

1982 • 1,171 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

A general method for site-directed mutagenesis in prokaryotes

1981 • 697 citations

Cyclic Adenosine Monophosphate and Alteration of Chinese Hamster Ovary Cell Morphology: a Rapid, Sensitive In Vitro Assay for the Enterotoxins of Vibrio cholerae and Escherichia coli

1974 • 572 citations

Transfer of the drug-resistance transposon Tn5 to Rhizobium

1978 • 483 citations

TRANSLATIONAL COUPLING DURING EXPRESSION OF THE TRYPTOPHAN OPERON OF ESCHERICHIA COLI

1980 • 384 citations

The arrangement of subunits in chlorea toxin

1976 • 337 citations

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1980 • 328 citations

Bacteriophage T7 early promoters: Nucleotide sequences of two RNA polymerase binding sites

1975 • 303 citations

Cholera

1973 • 294 citations

A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast

1983 • 288 citations

Cistrons encoding Escherichia coli heat-labile toxin

1979 • 273 citations

Comparison of the Tissue Receptors for Vibrio cholerae and Escherichia coli Enterotoxins by Means of Gangliosides and Natural Cholera Toxoid

1973 • 261 citations

Duration of Infection-Derived Immunity to Cholera

1981 • 255 citations

Termination of transcription and its regulation in the tryptophan operon of E. coli

1981 • 250 citations

Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition.

1979 • 230 citations

Directed transposon Tn5 mutagenesis and complementation analysis of rhizobium meliloti symbiotic nitrogen fixation genes

1982 • 212 citations

Response of Man to Infection with Vibrio cholerae. II. Protection from Illness Afforded by Previous Disease and Vaccine

1974 • 184 citations

Multi-functional Proteins

1981 • 164 citations

Construction and characterization of new cloning vehicles V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328

1981 • 148 citations

Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12.

1982 • 144 citations

Immunological Cross-Reactivity Between a Heat-Labile Enterotoxin(s) of Escherichia coli and Subunits of Vibrio cholerae Enterotoxin

1978 • 133 citations

Acute enteric infections in children - new prospects for treatment and prevention

1982 • 110 citations

Nucleotide sequence homology between the heat-labile enterotoxin gene of Escherichia coli and Vibrio cholerae deoxyribonucleic acid

1980 • 109 citations

Primary Structure of Cholera Toxin β-Chain: A Glycoprotein Hormone Analog?

1977 • 106 citations

Escherichia coli heat-labile enterotoxin. Nucleotide sequence of the A subunit gene.

1982 • 104 citations

Selection and characteristics of a Vibrio cholerae mutant lacking the A (ADP-ribosylating) portion of the cholera enterotoxin.

1979 • 104 citations

Determination of the primary structure of cholera toxin B subunit.

1977 • 95 citations

Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants

1978 • 90 citations

Studies on Toxinogenesis in Vibrio cholerae. I. Isolation of Mutants with Altered Toxinogenicity

1974 • 89 citations

Acute enteric infections in Children: New prospects for treatment and prevention

1983 • 57 citations

Chemical Characterization of the Stmcture of Cholera Toxin and Its Natural Toxoid

1976 • 50 citations

Isolation of enterotoxin structural gene deletion mutations in Vibrio cholerae induced by two mutagenic vibriophages.

1982 • 50 citations

Altered amino acid sequences produced by reversion of frameshift mutants of tryptophan synthetase A gene of E. coli.

1967 • 38 citations

Nucleotide sequence of the Q gene and the Q to S intergenic region of bacteriophage lambda

1982 • 38 citations

A Prototype Live Oral Cholera Vaccine

1971 • 34 citations

Location and the primary structure around the disulfide bonds in cholera toxin

1975 • 34 citations

Genetic mapping of mutations in independently isolated nontoxinogenic mutants of Vibrio cholerae

1978 • 32 citations

PRELIMINARY STUDIES ON THE DEVELOPMENT OF A LIVE ORAL VACCINE FOR ANTI-CHOLERA IMMUNIZATION.

1963 • 24 citations

Primary structure of cholera toxin subunit A₁

1979 • 21 citations

Regulation of cholera toxin production in Vibrio cholerae: genetic analysis of phenotypic instability in hypertoxinogenic mutants

1980 • 20 citations

Efficacy of a live oral cholera vaccine in human volunteers.

1976 • 19 citations

An overview of toxin-receptor interactions

1981 • 12 citations