Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle

1986 • 529 citations

Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

1968 • 406 citations

Kinetics of Hyperplasia in Psoriasis

1963 • 316 citations

Cell Death by Apoptosis in Epidermal Biology

1993 • 296 citations

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1993 • 292 citations

Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro

1995 • 291 citations

The complexities of proliferating cell nuclear antigen

1992 • 262 citations

Programmed Cell Death in Terminally Differentiating Keratinocytes: Role of Endogenous Endonuclease

1991 • 248 citations

Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.

1995 • 248 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

1995 • 220 citations

Increased nuclear cyclin/PCNA antigen staining of non S‐phase transformed human amnion cells engaged in nucleotide excision DNA repair

1986 • 172 citations

Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones

1989 • 164 citations

Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo.

1995 • 146 citations

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

1995 • 144 citations

Flow cytometric identification of proliferative subpopulations within normal human epidermis and the localization of the primary hyperproliferative population in psoriasis.

1993 • 131 citations

Altered keratinocyte growth and differentiation in psoriasis

1995 • 123 citations

Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics.

1994 • 107 citations

Changes in Expression of Apoptosis-Associated Genes in Skin Mark Early Catagen

1995 • 100 citations

Clonogenic Cells and Stem Cells in Epidermis

1973 • 99 citations

Epidermal 'turnover time'—a new examination

1977 • 86 citations

Bcl‐2 protooncogene expression in cervical carcinoma cell lines containing inactive p53

1995 • 76 citations

Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes

1996 • 75 citations

Abnormal Bcl-2 and “Tissue” Transglutaminase Expression in Psoriatic Skin

1994 • 72 citations

Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells.

1995 • 64 citations

Apoptosis: the skin from a new perspective.

1994 • 62 citations

Additive and synergistic antiproliferative effects of cyclosporin A and gamma interferon on cultured human keratinocytes.

1988 • 60 citations

Apoptosis in keratinocytes is not dependent on induction of differentiation.

1997 • 58 citations

Transforming Growth Factor-β1 Inhibits Nucleosomal Fragmentation in Human Keratinocytes following Loss of Adhesion

1996 • 35 citations

Comparative effects of growth inhibitors on DNA replication, DNA repair, and protein synthesis in human epidermal keratinocytes.

1986 • 14 citations

Programmed Cell Death: A rich harvest

1994 • 14 citations