Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons

1988 • 739 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene

1993 • 631 citations

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S

1980 • 618 citations

Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest

1993 • 556 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

Two rhombomeres are altered in Hoxa-1 mutant mice

1993 • 391 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

1993 • 352 citations

Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain

1993 • 340 citations

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

1992 • 330 citations

Analysis of larval segmentation in lethal genotypes associated with the Antennapedia gene complex in Drosophila melanogaster

1981 • 325 citations

A molecular analysis of mouse development from 8 to 10 dayspost coitumdetects changes only in embryonic globin expression

1987 • 298 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

1992 • 230 citations

Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis

1993 • 229 citations

Early regionalization of the somitic mesoderm as studied by the development of the axial skeleton of the chick embryo

1972 • 222 citations

Targeted Gene Replacement

1994 • 217 citations

Interactions between somite cells: the formation and maintenance of segment boundaries in the chick embryo

1987 • 215 citations

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.

1989 • 212 citations

Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development

1989 • 211 citations

Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells

1985 • 209 citations

Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene.

1993 • 183 citations

Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.

1988 • 172 citations

Developmental anomalies at the thoracic outlet: An analysis of 200 consecutive cases

1992 • 159 citations

The contribution made by a single somite to the vertebral column: experimental evidence in support of resegmentation using the chick–quail chimaera model

1988 • 148 citations

A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.

1986 • 134 citations

Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.

1987 • 130 citations

Patterning in the vertebrate limb

1991 • 114 citations

Introduction and Review of the Literature

1985 • 105 citations

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

1989 • 100 citations

Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network

1990 • 98 citations

Expression and modification of Hox 2.1 protein in mouse embryos

1992 • 91 citations

Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.

1992 • 81 citations

Coding sequence and expression of the homeobox gene Hox 1.3

1988 • 78 citations

A role for Quox-8 in the establishment of the dorsoventral pattern during vertebrate development.

1992 • 69 citations

Introduction

1988 • 63 citations

Genetical studies on the skeleton of the mouse. I. Minor variations of the vertebral column.

1950 • 57 citations

Genetical studies on the skeleton of the mouse

1950 • 47 citations

Conservation and Divergence of Patterns of Expression and Lineage-Specific Transcripts in Orthologues and Paralogues of the Mouse Hox-1.4 Gene

1993 • 30 citations

Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes

1992 • 29 citations

Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes

1992 • 25 citations

Identification of homeobox-containing genes expressed in hematopoietic blast cells

1992 • 21 citations

First rib abnormalities in association with cervical ribs: A cause for postoperative failure in the thoracic outlet syndrome

1992 • 10 citations

Cell-surface changes induced by ectopic expression of the murine homeo☐ gene Hox-3.3

1992 • 4 citations