An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Seventy-five percent accuracy in protein secondary structure prediction

1997 • 377 citations

The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein

1993 • 241 citations

VIRAL TRANSACTIVATING PROTEINS

1997 • 233 citations

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1989 • 232 citations

Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus

1995 • 228 citations

Biochemical Analysis of Distinct Activation Functions in p300 That Enhance Transcription Initiation with Chromatin Templates

1999 • 227 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Activator-Dependent Transcription from Chromatin In Vitro Involving Targeted Histone Acetylation by p300

2000 • 200 citations

Loss of HCF-1–Chromatin Association Precedes Temperature-Induced Growth Arrest of tsBN67 Cells

2001 • 193 citations

Luman, a New Member of the CREB/ATF Family, Binds to Herpes Simplex Virus VP16-Associated Host Cellular Factor

1997 • 173 citations

The virion transactivator of herpes simplex virus

1993 • 155 citations

A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.

1997 • 144 citations

Regulation of herpes simplex virus gene expression

2001 • 136 citations

Deletion of the VP16 open reading frame of herpes simplex virus type 1

1992 • 136 citations

Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP

1997 • 132 citations

Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

1996 • 131 citations

Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency

1999 • 128 citations

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

1991 • 128 citations

The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins.

1989 • 127 citations

The Cellular C1 Factor of the Herpes Simplex Virus Enhancer Complex Is a Family of Polypeptides

1995 • 109 citations

VP16 Targets an Amino-Terminal Domain of HCF Involved in Cell Cycle Progression

1997 • 101 citations

Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16).

1993 • 98 citations

Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16

2000 • 96 citations

The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF

1998 • 95 citations

The HCF repeat is an unusual proteolytic cleavage signal.

1995 • 94 citations

The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP

2000 • 91 citations

Rho GTPases as Modulators of the Estrogen Receptor Transcriptional Response

2001 • 90 citations

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

2000 • 80 citations

Anatomy of an enhancer

1992 • 75 citations

Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture

2000 • 66 citations

Combinatorial Control of Transcription: The Herpes Simplex Virus VP16-induced Complex

1993 • 61 citations

Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 produces a phenotype similar to that of the in1814 linker insertion mutation

1997 • 56 citations

Truncation of the C-Terminal Acidic Transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0

1999 • 54 citations

HCF-1 Amino- and Carboxy-Terminal Subunit Association through Two Separate Sets of Interaction Modules: Involvement of Fibronectin Type 3 Repeats

2000 • 49 citations

The gene encoding the VP16-accessory protein HCF (HCFC1) resides in human Xq28 and is highly expressed in fetal tissues and the adult kidney

1995 • 48 citations

Concerted Activity of Host Cell Factor Subregions in Promoting Stable VP16 Complex Assembly and Preventing Interference by the Acidic Activation Domain

1997 • 47 citations

DNA Recognition by the Herpes Simplex Virus Transactivator VP16: a Novel DNA-Binding Structure

2001 • 46 citations

The Herpes Simplex Virus VP16-induced Complex: Mechanisms of Combinatorial Transcriptional Regulation

1998 • 46 citations

Artificial Recruitment of TFIID, but Not RNA Polymerase II Holoenzyme, Activates Transcription in Mammalian Cells

2000 • 45 citations

The Transcriptional Activation Domain of VP16 Is Required for Efficient Infection and Establishment of Latency by HSV-1 in the Murine Peripheral and Central Nervous Systems

1999 • 42 citations

N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif

2000 • 40 citations

Analysis of HCF, the Cellular Cofactor of VP16, in Herpes Simplex Virus-Infected Cells

2000 • 36 citations

Positive and Negative Regulation at the Herpes Simplex Virus ICP4 and ICPO TAATGARAT Motifs

1995 • 33 citations

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements

1997 • 31 citations

Analysis of Functional Domains of the Host Cell Factor Involved in VP16 Complex Formation

1999 • 29 citations

The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions

1997 • 25 citations