Truncation of the C-Terminal Acidic Transcriptional Activation Domain of Herpes Simplex Virus VP16 Renders Expression of the Immediate-Early Genes Almost Entirely Dependent on ICP0

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins

1974 • 1,479 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

1997 • 484 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms

1998 • 402 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins

1998 • 373 citations

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

1989 • 372 citations

Network model of shape-from-shading: neural function arises from both receptive and projective fields

1988 • 369 citations

HSV-1 IE protein Vmw110 causes redistribution of PML.

1994 • 354 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)

1993 • 316 citations

Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes

1982 • 315 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0

1994 • 281 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells

1992 • 257 citations

Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase

1999 • 255 citations

Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110

1999 • 251 citations

Physical mapping of herpes simplex virus-induced polypeptides

1978 • 248 citations

Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3

1997 • 246 citations

Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

1985 • 242 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency

1993 • 233 citations

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1989 • 232 citations

The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27

1997 • 188 citations

Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery

1997 • 185 citations

An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1

1995 • 179 citations

Construction and Characterization of Herpes Simplex Virus Type 1 Mutants with Defined Lesions in Immediate Early Gene 1

1989 • 177 citations

Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0

1996 • 174 citations

Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus

1988 • 169 citations

Stimulation of Expression of a Herpes Simplex Virus DNA-Binding Protein by Two Viral Functions

1985 • 165 citations

Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes.

1985 • 164 citations

VP16 interacts via its activation domain with VP22, a tegument protein of herpes simplex virus, and is relocated to a novel macromolecular assembly in coexpressing cells

1995 • 158 citations

The virion transactivator of herpes simplex virus

1993 • 155 citations

Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs

1994 • 151 citations

Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system

1989 • 132 citations

Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

1996 • 131 citations

Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function

1994 • 124 citations

DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters

1985 • 122 citations

The Ability of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 To Bind to a Ubiquitin-Specific Protease Contributes to Its Roles in the Activation of Gene Expression and Stimulation of Virus Replication

1999 • 122 citations

Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion

1980 • 121 citations

A viral activator of gene expression functions via the ubiquitin-proteasome pathway

1998 • 119 citations

A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1

1991 • 114 citations

ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase

1998 • 99 citations

Herpes simplex virus Vmw65-octamer binding protein interaction: A paradigm for combinatorial control of transcription

1989 • 97 citations

Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65

1989 • 96 citations

Mutational Analysis of the Herpes Simplex Virus Type 1 Trans-inducing Factor Vmw65

1988 • 96 citations

A Herpes Simplex Virus Type 1 Mutant Containing a Deletion within Immediate Early Gene 1 Is Latency-competent in Mice

1989 • 95 citations

Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products

1990 • 95 citations

Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis

1997 • 94 citations

Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene

1997 • 93 citations

Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants

1995 • 87 citations

Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures

1995 • 87 citations

Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis

1997 • 85 citations

Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1

1992 • 85 citations

Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Binds Strongly and Specifically to a 135-kDa Cellular Protein

1994 • 82 citations

Anatomy of an enhancer

1992 • 75 citations

Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65

1992 • 70 citations

Identification and Characterization of the Virion Protein Products of Herpes Simplex Virus Type 1 Gene UL47

1990 • 68 citations

Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences

1990 • 67 citations

Establishment of latency in vitro by the herpes simplex virus type 1 mutant in 1814

1991 • 65 citations

Functional and genetic analysis of the role of Vmw110 in herpes simplex virus replication

1991 • 59 citations

The Effect of Herpes Simplex Virus Type 1 L-Particles on Virus Entry, Replication, and the Infectivity of Naked Herpesvirus DNA

1997 • 57 citations

Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 produces a phenotype similar to that of the in1814 linker insertion mutation

1997 • 56 citations

Construction and Characterization of Herpes Simplex Virus Type 1 Mutants with Conditional Defects in Immediate Early Gene Expression

1997 • 53 citations

Mapping of a major surface-exposed site in herpes simplex virus protein Vmw65 to a region of direct interaction in a transcription complex assembly

1993 • 49 citations

Complementation of a Herpes Simplex Virus Type 1 Vmw110 Deletion Mutant by Human Cytomegalovirus

1989 • 49 citations

Herpes simplex virus type 1 immediate early gene expression is stimulated by inhibition of protein synthesis.

1998 • 43 citations

The herpes simplex virus type 1 immediate-early protein ICP0 is necessary for the efficient establishment of latent infection

1997 • 42 citations

Herpes simplex virus immediate early gene expression in the absence of transinduction by Vmw65 varies during the cell cycle

1992 • 19 citations

The NH ₂ Terminus of the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Contains a Promoter-Specific Transcription Activation Domain

1998 • 19 citations

Influence of the Host Cell on the Association of ICP4 and ICP0 with Herpes Simplex Virus Type 1

1995 • 18 citations