The Transcriptional Activation Domain of VP16 Is Required for Efficient Infection and Establishment of Latency by HSV-1 in the Murine Peripheral and Central Nervous Systems

‘Touchdown’ PCR to circumvent spurious priming during gene amplification

1991 • 2,630 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

Latent Herpes Simplex Virus in Spinal Ganglia of Mice

1971 • 567 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex

1991 • 464 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes

1983 • 423 citations

Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map

1973 • 379 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Structure and function of transcriptional activation domains

1995 • 376 citations

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

1989 • 372 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Identification of Ets- and Notch-Related Subunits in GA Binding Protein

1991 • 358 citations

Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes

1982 • 315 citations

Herpes Simplex Virus Infections of the Central Nervous System: Therapeutic and Diagnostic Considerations

1995 • 313 citations

The Human Herpesviruses

1993 • 301 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.

1993 • 285 citations

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence

1991 • 256 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein

1993 • 241 citations

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1989 • 232 citations

Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.

1995 • 191 citations

Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules

1995 • 183 citations

Establishment and Characterization of the Human Medulloblastoma Cell Line and Transplantable Xenograft D283 Med

1985 • 182 citations

Herpes simplex virus latency

1984 • 180 citations

A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats

1994 • 178 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 177 citations

Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies

1983 • 173 citations

A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia

1990 • 170 citations

Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis

1995 • 163 citations

Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs

1994 • 151 citations

Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome

1988 • 140 citations

Deletion of the VP16 open reading frame of herpes simplex virus type 1

1992 • 136 citations

Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

1996 • 131 citations

A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation

1985 • 128 citations

Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence

1983 • 128 citations

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

1991 • 128 citations

The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins.

1989 • 127 citations

Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures

1997 • 123 citations

Neurons Derived from a Human Teratocarcinoma Cell Line Establish Molecular and Structural Polarity Following Transplantation into the Rodent Brain

1993 • 122 citations

Herpes simplex genes: the blueprint of a succesful human pathogen

1994 • 122 citations

Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant.

1995 • 121 citations

The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1

1987 • 121 citations

Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex

1990 • 116 citations

Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene

1984 • 113 citations

A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.

1990 • 109 citations

Treatment of Experimental Intracranial Murine Melanoma with a Neuroattenuated Herpes Simplex Virus 1 Mutant

1995 • 108 citations

Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes.

1989 • 105 citations

A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells

1989 • 101 citations

Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16).

1993 • 98 citations

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat.

1985 • 89 citations

Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia

1991 • 86 citations

Structural basis of C3b binding by glycoprotein C of herpes simplex virus

1992 • 68 citations

Viral, neuronal and immune factors which may influence herpes simplex virus (HSV) latency and reactivation

1993 • 65 citations

[The herpes viruses].

1975 • 65 citations

Transcriptional Activation by the Acidic Domain of Vmw65 Requires the Integrity of the Domain and Involves Additional Determinants Distinct from Those Necessary for TFIIB Binding

1993 • 65 citations

Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus [published erratum appears in Nucleic Acids Res 1998 Dec 1;26(23):537-8]

1998 • 60 citations

A review of the molecular mechanism of HSV-1 latency

1991 • 58 citations

Truncation of the C-terminal acidic transcriptional activation domain of herpes simplex virus VP16 produces a phenotype similar to that of the in1814 linker insertion mutation

1997 • 56 citations

The herpes simplex virus type 1 strain 17+ 34.5 deletion mutant 1716 is avirulent in SCID mice

1994 • 56 citations

Investigation of herpes simplex virus type 1 (HSV-1) gene expression and DNA synthesis during the establishment of latent infection by an HSV-1 mutant, in1814, that does not replicate in mouse trigeminal ganglia

1991 • 53 citations

Interaction between the octamer-binding protein nuclear factor III and the adenovirus origin of DNA replication

1988 • 51 citations

Therapy of a Murine Model of Pediatric Brain Tumors using a Herpes Simplex Virus Type-1 ICP34.5 Mutant and Demonstration of Viral Replication within the CNS

1996 • 45 citations

Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice

1992 • 40 citations

Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16

1996 • 39 citations

A Thymidine Kinase-Negative HSV-1 Strain Establishes a Persistent Infection in SCID Mice That Features Uncontrolled Peripheral Replication but Only Marginal Nervous System Involvement

1994 • 35 citations

Cellular Transcription Factors Enhance Herpes Simplex Virus Type 1 oriS-Dependent DNA Replication

1998 • 31 citations

Selective Vulnerability of Mouse CNS Neurons to Latent Infection with a Neuroattenuated Herpes Simplex Virus-1

1996 • 29 citations

Toxicity and Neuronal Infection of a HSV-1 ICP34.5 Mutant in Nude Mice

1998 • 29 citations

Transcriptional activation by the acidic domain of Vmw65 requires the integrity of the domain and involves additional determinants distinct from those necessary for TFIIB binding.

1993 • 28 citations

In vivo and in vitro models of medulloblastomas and other primitive neuroectodermal brain tumors of childhood

1994 • 25 citations

The immunocytochemical detection of Herpes simplex virus in cervical smears—a valuable technique for routine use

1984 • 19 citations

The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines

1995 • 18 citations

Properties of the Herpes Simplex Virus Type 2 Trans-inducing Factor Vmw65 in Wild-type and Mutant Viruses

1989 • 7 citations