Regulation of Genetic Expression in Shear Stress–stimulated Endothelial Cellsa

Inositol phosphates and cell signalling

1989 • 4,058 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Haemodynamic shear stress activates a K+ current in vascular endothelial cells

1988 • 1,003 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

1987 • 703 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.

1988 • 518 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

Stretching cardiac myocytes stimulates protooncogene expression.

1990 • 470 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells

1989 • 448 citations

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

1983 • 446 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Modularity in promoters and enhancers

1989 • 366 citations

Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production

1990 • 343 citations

jun:Oncogene and Transcription Factor

1990 • 337 citations

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.

1990 • 290 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress

1990 • 276 citations

Isolation and characterization of fra-2, an additional member of the fos gene family.

1990 • 274 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

From Epinephrine to Cyclic AMP

1988 • 255 citations

The human tissue plasminogen activator gene.

1986 • 230 citations

Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

1990 • 226 citations

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

1988 • 221 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells

1991 • 198 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences.

1988 • 170 citations

Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements.

1990 • 162 citations

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

1990 • 155 citations

Distinct Adenosine 3′,5′-Monophosphate and Phorbol Ester-Responsive Signal Transduction Pathways Converge at the Level of Transcriptional Activation by the Interactions of DNA-Binding Proteins

1989 • 151 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

Hydrodynamic shear stress and mass transport modulation of endothelial cell metabolism

1991 • 142 citations

Mechanism of shear-induced prostacyclin production in endothelial cells

1989 • 136 citations

Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation.

1988 • 130 citations

Cyclic AMP potentiates phorbol ester stimulation of tissue plasminogen activator release and inhibits secretion of plasminogen activator inhibitor-1 from human endothelial cells.

1988 • 112 citations

Cyclical strain effects on production of vasoactive materials in cultured endothelial cells

1992 • 108 citations

Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation

1988 • 108 citations

Activation of junB by PKC and PKA signal transduction through a novelcis-acting element

1991 • 96 citations

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping "leucine zippers"

1989 • 90 citations

Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.

1990 • 87 citations

Growth factor-responsive genes in fibroblasts.

1990 • 87 citations

Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions

1990 • 81 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

The effect of shear stress on the uptake and metabolism of arachidonic acid by human endothelial cells

1989 • 63 citations

The human von Willebrand factor gene

1988 • 41 citations

DNA‐binding activity of jun is increased through its interaction with Fos

1990 • 36 citations

Fos, Jun and CREB basic-domain peptides have intrinsic DNA-binding activity enhanced by a novel stabilizing factor.

1990 • 30 citations

cAMP mediates IL-1-induced lymphocyte penetration through endothelial monolayers.

1990 • 28 citations

Transcription of -2 mRNA and phosphorylation of Fra-2 protein are stimulated by serum

1991 • 17 citations