Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Activity-dependent neuronal plasticity following tissue injury and inflammation

1992 • 933 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding

1988 • 435 citations

The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation

1992 • 422 citations

Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms

1989 • 395 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

1992 • 370 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 286 citations

Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

1990 • 259 citations

The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats

1992 • 242 citations

N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint

1993 • 194 citations

Enhancement of the responses of ascending tract cells in the cat spinal cord by acute inflammation of the knee joint

1987 • 192 citations

Characterization of the binding of [³H]‐CGS 19755: a novel N‐methyl‐<scp>d</scp>‐aspartate antagonist with nanomolar affinity in rat brain

1988 • 164 citations

Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy

1990 • 156 citations

Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus.

1987 • 107 citations

Modifications in the responsiveness of rat ventrobasal thalamic neurons at different stages of carrageenin-produced inflammation

1986 • 81 citations

Responses of neurons in the rat thalamic nucleus submedius to cutaneous, muscle and visceral nociceptive stimuli

1993 • 74 citations

Thalamic NMDA receptors and nociceptive sensory synaptic transmission

1990 • 70 citations

Spinal Mediators of Hyperalgesia

1994 • 68 citations

Enrichment of glutamate immunoreactivity in lemniscal terminals in the ventropostero lateral thalamic nucleus of the rat: An immunogold and WGA‐HRP study

1994 • 40 citations

The function of metabotropic excitatory amino acid receptors in synaptic transmission in the thalamus: Studies with novel phenylglycine antagonists☆

1994 • 38 citations

Neuronal response thresholds to and encoding of thermal stimuli during carrageenin-hyperalgesic-inflammation in the ventro-basal thalamus of the rat

1987 • 35 citations

Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus

1996 • 32 citations

Chapter 14 Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products

1996 • 32 citations

Thresholds and encoding of neuronal responses to mechanical stimuli in the ventro-basal thalamus during carrageenin-induced hyperalgesic inflammation in the rat

1987 • 29 citations

The ventral posterior nucleus of thalamus is involved in the generation of central pain syndromes

1992 • 20 citations

Responses of lateral thalamic neurons to algesic chemical stimulation of the cat knee joint

1994 • 13 citations

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