Minireview: Genomic Organization of the Human ERα Gene Promoter Region

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.

1986 • 733 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

CONTROL OF TRANSLATION INITIATION IN ANIMALS

1998 • 507 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

Molecular cloning and charcterization of rat estrogen receptor cDNA

1987 • 488 citations

Genomic organization of the human oestrogen receptor gene.

1988 • 480 citations

Cytokines and Estrogen in Bone: Anti-Osteoporotic Effects

1993 • 466 citations

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

2000 • 459 citations

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

2000 • 405 citations

Structural Organization and Expression of the Mouse Estrogen Receptor

1987 • 365 citations

Identification and Estrogen Induction of Two Estrogen Receptors (ER) Messenger Ribonucleic Acids in the Rainbow Trout Liver: Sequence Homology with other ERs

1989 • 171 citations

Differentially Expressed Messenger RNA Isoforms of the Human Estrogen Receptor-α Gene Are Generated by Alternative Splicing and Promoter Usage

1998 • 158 citations

ERα Gene Expression in Human Primary Osteoblasts: Evidence for the Expression of Two Receptor Proteins

2001 • 152 citations

Identification of ERF-1 as a member of the AP2 transcription factor family

1997 • 142 citations

Localization of the human oestrogen receptor gene to chromosome 6q24→q27 by in situ hybridization

1986 • 111 citations

AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs

1999 • 109 citations

EVIDENCE FOR A PREVIOUSLY UNIDENTIFIED UPSTREAM EXON IN THE HUMAN OESTROGEN RECEPTOR GENE.

1991 • 107 citations

Transcriptional Regulation of Estrogen Receptor in Breast Carcinomas

1995 • 104 citations

Estrogen target tissue determines alternative promoter utilization of the human estrogen receptor gene in osteoblasts and tumor cell lines.

1995 • 104 citations

Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform

1996 • 101 citations

Two Estrogen Receptor (ER) Isoforms with Different Estrogen Dependencies Are Generated from the Trout ER Gene1

2000 • 94 citations

The Human Brain Has Distinct Regional Expression Patterns of Estrogen Receptor α mRNA Isoforms Derived from Alternative Promoters

2000 • 94 citations

Multiple splicing variants of the estrogen receptor are present in individual human breast tumors

1996 • 83 citations

Auto-regulation of the estrogen receptor promoter

1997 • 81 citations

Selective Promoter Usage of the Human Estrogen Receptor-α Gene and Its Regulation by Estrogen

1999 • 75 citations

Analysis of upstream sequences of the human estrogen receptor gene

1992 • 62 citations

A Transcriptional Enhancer Required for the Differential Expression of the Human Estrogen Receptor in Breast Cancers

1997 • 61 citations

Tissue‐specific expression of multiple mRNA variants of the mouse estrogen receptor α gene

2000 • 60 citations

Sequencing of an RNA transcript of the human estrogen receptor gene: Evidence for a new transcriptional event

1993 • 56 citations

Overexpression of rainbow trout estrogen receptor domains in Escherichia coli: characterization and utilization in the production of antibodies for immunoblotting and immunocytochemistry

1994 • 51 citations

Two Functionally Different Protein Isoforms Are Produced from the Chicken Estrogen Receptor-α Gene

1999 • 51 citations

Regulation of estrogen receptor gene mediated by promoter B responsible for its enhanced expression in human breast cancer

1999 • 50 citations

Localization of DNase I hypersensitive sites in the human oestrogen receptor gene correlates with the transcriptional activity of two differentially used promoters

1993 • 50 citations

Identification of two estrogen receptor transcripts with novel 5′ exons isolated from a MCF7 cDNA library

1997 • 48 citations

Quantitative analysis of the transcriptional start sites of estrogen receptor in breast carcinoma.

1995 • 44 citations

Human Estrogen Receptor (ER) Gene Promoter-P1: Estradiol-Independent Activity and Estradiol Inducibility in ER+ and ER− Cells

1997 • 44 citations

Genomic Structure of the Promoters of the Human Estrogen Receptor-α Gene Demonstrate Changes in Chromatin Structure Induced by AP2γ

2001 • 39 citations

The multiple untranslated first exons and promoters system of the oestrogen receptor gene in the brain and peripheral tissues of the rat and monkey and the developing rat cerebral cortex

1998 • 33 citations

The 5′ flank of the rat estrogen receptor gene: structural characterization and evidence for tissue- and species-specific promoter utilization

1996 • 32 citations

The Novel Untranslated First Exon “Exon 0N” of the Rat Estrogen Receptor Gene

1996 • 30 citations

The untranslated first exon ‘exon OS’ of the rat estrogen receptor (ER) gene

1996 • 29 citations

Cis element ‘decoy’ against the upstream promoter of the human estrogen receptor gene

2000 • 25 citations

Identification of Novel Chicken Estrogen Receptor-α Messenger Ribonucleic Acid Isoforms Generated by Alternative Splicing and Promoter Usage**This work was supported by the Irish American Partnership (to C.G.), the Irish Cancer Society, and an EMBO long term fellowship (to G.F.).

1998 • 24 citations

Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer

1999 • 21 citations

Estrogen Receptor mRNA Variants

1996 • 20 citations

Estrogen receptor mRNA splice variants produced from the distal and proximal promoter transcripts

1998 • 16 citations