The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Status epilepticus in well–oxygenated rats causes neuronal necrosis

1985 • 312 citations

Neuronal Vacuolization and Necrosis Induced by the Noncompetitive N-methyl-d-aspartate (NMDA) Antagonist MK(+)801 (Dizocilpine Maleate): A Light and Electron Microscopic Evaluation of the Rat Retrosplenial Cortex

1993 • 257 citations

Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

1988 • 244 citations

MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain

1989 • 161 citations

Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat

1989 • 159 citations

N‐Methyl‐D‐Aspartate antagonist reduces stroke size and regional glucose metabolism

1990 • 155 citations

The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke

1992 • 142 citations

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat

1990 • 112 citations

Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use

1989 • 106 citations

Lack of effect of L‐687,414 ((+)‐cis‐4‐methyl‐HA‐966)₅ an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology

1993 • 89 citations

The subcellular distribution of calcium and the effects of calcium-antagonists as evaluated with a combined oxalate-pyroantimonate technique.

1981 • 68 citations

Effect of MK-801 on focal brain infarction in normotensive and hypertensive rats.

1992 • 58 citations

Autoradiographic assessment of the effects of N-methyl-d-aspartate (NMDA) receptor antagonists in vivo

1991 • 56 citations

Metabolic Alterations Underlying the Development of Hypermetabolic Necrosis in the Substantia Nigra in Status Epilepticus

1987 • 55 citations

SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons

1992 • 50 citations

Early axonal lesion and preserved microvasculature in epilepsy-induced hypermetabolic necrosis of the substantia nigra

1986 • 41 citations

Competitive (AP7) and non‐competitive (MK‐801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex

1991 • 27 citations

Cerebral blood flow and ischemia-induced neurotransmitter release in the striatum of aged spontaneously hypertensive rats.

1993 • 19 citations