Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

New Insights into the Control of MAP Kinase Pathways

1999 • 431 citations

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

1999 • 348 citations

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

1984 • 302 citations

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

1998 • 298 citations

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.

1992 • 191 citations

Inhibition of T Cell Activation by Pharmacologic Disruption of the MEK1/ERK MAP Kinase or Calcineurin Signaling Pathways Results in Differential Modulation of Cytokine Production

1998 • 190 citations

Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes

1986 • 188 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells

1999 • 179 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Role of phosphatases in lymphocyte activation

1997 • 154 citations

Microdomains in lymphocyte signalling: beyond GPI-anchored proteins

2000 • 135 citations

p38 Kinase Is a Negative Regulator of Angiotensin II Signal Transduction in Vascular Smooth Muscle Cells

1998 • 131 citations

Induction of T cell activation by monoclonal anti-Thy-1 antibodies.

1986 • 125 citations

Thymocytes in Thy-1−/− mice show augmented TCR signaling and impaired differentiation

1997 • 123 citations

TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor

1988 • 112 citations

Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.

1997 • 98 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

p38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression

1999 • 76 citations

Role of phosphatidylinositol-anchored proteins in T cell activation.

1990 • 67 citations

Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C.

1996 • 61 citations

T-cell regulation: Thy-1 – hiding in full view

1997 • 49 citations

Impaired Cutaneous Immune Responses in Thy-1-Deficient Mice

1998 • 46 citations

Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.

1997 • 44 citations

Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.

1995 • 36 citations

Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT

1999 • 32 citations

Antibody ligation of CD7 leads to association with phosphoinositide 3‐kinase and phosphatidylinositol 3,4,5‐trisphosphate formation in T lymphocytes

1995 • 27 citations

Thy-1: a lymphoid cell subset marker capable of delivering an activation signal to mouse T lymphocytes

1987 • 27 citations

Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells

1997 • 22 citations

Characterization of human CD7 transgenic mice.

1995 • 16 citations

The antitumor effect of tumor-draining lymph node cells activated by both anti-CD3 monoclonal antibody and activated B cells as costimulatory-signal-providing cells

1995 • 13 citations

Ultraviolet light activation of insect nuclear polyhedrosis virus

1975 • 5 citations

Dissociation of signal transduction via Thy-1 and CD3 antigens in murine T cells

1990 • 3 citations