Using ubiquitin to follow the metabolic fate of a protein.

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

The N-End Rule in Bacteria

1991 • 536 citations

Universality and Structure of the N-end Rule

1989 • 472 citations

The degradation signal in a short-lived protein

1989 • 427 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.

1994 • 367 citations

Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis.

1994 • 311 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

1992 • 250 citations

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

1990 • 243 citations

Cotranslational processing and protein turnover in eukaryotic cells

1988 • 201 citations

Sindbis virus RNA polymerase is degraded by the N-end rule pathway.

1991 • 175 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

Ubiquitin-assisted dissection of protein transport across membranes.

1994 • 113 citations

Yeast N-terminal Amidase

1995 • 100 citations

Inhibition of the N-end rule pathway in living cells.

1991 • 90 citations

A recognition component of the ubiquitin system is required for peptide transport in Saccharomyces cerevisiae

1995 • 59 citations

The N-end Rule

1995 • 56 citations