Atherosclerosis and Macrophages

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Secretory products of macrophages.

1987 • 2,670 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

1986 • 1,323 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

1980 • 727 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Chemotactic activity of elastin-derived peptides.

1980 • 519 citations

Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

1981 • 506 citations

Secretory products of macrophages and their physiological functions

1984 • 494 citations

Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats.

1983 • 487 citations

Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.

1980 • 475 citations

Enhanced macrophage degradation of biologically modified low density lipoprotein.

1983 • 469 citations

Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages.

1979 • 393 citations

The structure and biologic activities of plasma fibronectin

1980 • 385 citations

Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.

1980 • 377 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

1987 • 337 citations

The structure and biologic activities of plasma fibronectin

1980 • 325 citations

Collagen-and collagen peptide-induced chemotaxis of human blood monocytes.

1976 • 312 citations

Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations.

1979 • 297 citations

Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.

1985 • 295 citations

Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits

1958 • 270 citations

Secretory function of mononuclear phagocytes: a review.

1976 • 258 citations

Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.

1985 • 249 citations

Leukotactic Factor Produced by Sensitized Lymphocytes

1969 • 239 citations

Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children

1987 • 233 citations

T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis.

1988 • 226 citations

The arterial medial cell, smooth muscle or multifunctional mesenchyme?

1968 • 223 citations

Monocytic origin of foam cells in human atherosclerotic plaques

1984 • 202 citations

Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor.

1987 • 194 citations

Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg.

1985 • 192 citations

Collagen types in various layers of the human aorta and their changes with the atherosclerotic process

1986 • 189 citations

An immunohistochemical analysis of human aortic fatty streaks

1987 • 177 citations

Control of monocyte recruitment by chemotactic factor(s) in lesion-prone areas of swine aorta.

1985 • 163 citations

Regulation of production of a platelet‐derived growth factor‐like protein by cultured bovine aortic endothelial cells

1984 • 158 citations

Adhesion of leukocytes to endothelium: Roles of divalent cations, surface charge, chemotactic agents and substrate

1980 • 157 citations

Role of macrophages in atherosclerosis. Sequential observations of cholesterol-induced rabbit aortic lesion by the immunoperoxidase technique using monoclonal antimacrophage antibody.

1985 • 157 citations

In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis.

1983 • 151 citations

Morphological characterization of the cholesteryl ester cycle in cultured mouse macrophage foam cells.

1983 • 145 citations

Collagen αB Chain: Increased Proportion in Human Atherosclerosis

1981 • 139 citations

Synthesis of Connective Tissue Macromolecules by Smooth Muscle

1979 • 128 citations

Identification of foam cells in human atherosclerotic lesions as macrophages using monoclonal antibodies.

1985 • 122 citations

INTERACTIONS OF PLASMA LIPOPROTEINS WITH ENDOTHELIAL CELLS*

1982 • 114 citations

Endothelial surface characteristics in pigeon coronary artery atherosclerosis. I. Cellular alterations during the initial stages of dietary cholesterol challenge.

1982 • 114 citations

Increased serum lipid peroxides initiate atherogenesis

1984 • 106 citations

Lipids of human atheroma Part 5. The occurrence of a new group of polar sterol esters in various stages of human atherosclerosis

1971 • 106 citations

LDL enhances monocyte adhesion to endothelial cells in vitro.

1986 • 103 citations

LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblast

1983 • 100 citations

Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation.

1984 • 90 citations

Platelets stimulate aortic smooth muscle cell migration in vitro

1982 • 89 citations

The morphology of early atherosclerotic lesions of the aorta demonstrated by the surface technique in rabbits fed cholesterol; together with a description of the anatomy of the intima of the rabbit's aorta and the spontaneous lesions which occur in it.

1957 • 89 citations

Human arterial wall cells secrete factors that are chemotactic for monocytes.

1983 • 88 citations

Substratum-bound elastin peptide inhibits aortic smooth muscle cell migration in vitro.

1987 • 77 citations

Atherosclerosis- and age-related multinucleated variant endothelial cells in primary culture from human aorta.

1989 • 77 citations

Morphology and cell kinetics of fatty streak lesion formation in the hypercholesterolemic rabbit.

1986 • 76 citations

Aortic intimal monocyte recruitment in the normo and hypercholesterolemic baboon (Papio cynocephalus)

1985 • 74 citations

Human monocyte-endothelial cell interaction in vitro.

1985 • 71 citations

Effect of monocyte migration on low density lipoprotein transport across aortic endothelial cell monolayers.

1984 • 65 citations

Effects of moderate hypercholesterolemia on rabbit endothelium.

1981 • 64 citations

Cellular composition of hypersensitivity-type granulomas: Immunohistochemical analysis of tuberculous and sarcoidal lymphadenitis

1984 • 63 citations

Monocyte-Macrophage Participation in Atherogenesis: Inflammatory Components of Pathogenesis

1986 • 62 citations

Effect of probucol on macrophages, leading to regression of xanthomas and atheromatous vascular lesions

1988 • 62 citations

Mononuclear cell chemotactic activity of kallikrein and plasminogen activator and its inhibition by C1 inhibitor and alpha 2-macroglobulin.

1974 • 61 citations

Pathology of Atherosclerosis

1983 • 61 citations

Dietary cholesterol-induced changes in macrophage characteristics. Relationship to atherosclerosis.

1986 • 60 citations

Initial characterization of a peripheral blood mononuclear cell chemoattractant derived from cultured arterial smooth muscle cells.

1984 • 58 citations

Differences in predominant T cell phenotypes and distribution pattern in reactional lesions of tuberculoid and lepromatous leprosy.

1984 • 57 citations

On the cellular origin and development of atheromatous plaques

1983 • 56 citations

Monocyte adherence to endothelial cells in vitro is increased by beta-VLDL.

1987 • 53 citations

Detection of macrophages in atherosclerotic lesions with cytochrome oxidase.

1976 • 51 citations

Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of white carneau pigeons.

1986 • 48 citations

Fc-dependent binding of monocytes to areas with endothelial injury in the rabbit aorta

1981 • 47 citations

The Interaction of the High‐Density Lipoprotein with Cultured Cells of Bovine Vascular Endothelium

1981 • 47 citations

Phagocytes, lipid‐removal and regression of atheroma

1975 • 42 citations

Mononuclear Cell Chemotactic Activity of Kallikrein and Plasminogen Activator and Its Inhibition by C̄1 Inhibitor and α2-Macroglobulin

1974 • 40 citations

Development of semliki forest virus in mouse brain: An electron microscopic study

1970 • 39 citations

Electron microscopic study on permeability of the aorta and basilar artery of the rabbit—With special reference to the changes of permeability by hypercholesteremia

1975 • 38 citations

Injury to cultured endothelial cells from human umbilical vein by linoleic acid hydroperoxide.

1984 • 37 citations

Monocyte chemoattractants in pigeon aortic atherosclerosis.

1987 • 36 citations

Temporal arteritis: Cell composition and the possible pathogenetic role of cell-mediated immunity

1989 • 35 citations

Chemically modified low density lipoproteins as inducers of enzyme release from macrophages

1985 • 31 citations

The Activated Macrophage and Granulomatous Inflammation

1989 • 30 citations

Atherosclerosis and Inflammation

1978 • 28 citations

Hypercholesterolemia and Atherosclerosis: Pathogenesis and Prevention

1987 • 24 citations

Ultrastructural Aspects of Human Atherosclerosis; Role of the Foam Cells and Modified Smooth Muscle Cells

1972 • 23 citations

The role of macrophages and giant cells in advanced human atherosclerosis

1980 • 23 citations

Histochemical detection and quantification of macrophages in rhesus and cynomolgus monkey atherosclerotic lesions.

1984 • 20 citations

Formation of Lipid-Laden Cells from Cultured Aortic Smooth Muscle Cells and Macrophages by Linoleic Acid Hydroperoxide and Low Density Lipoprotein

1987 • 19 citations

Atherosclerotic lesions in coronary arteries of hyperlipidemic swine

1986 • 19 citations

Stimulation of Locomotion of Peripheral Blood Monocytes by Human Plasma Fibronectin

1983 • 17 citations

Involvement of macrophages in accumulation and elimination of cholesterol ester in atherosclerotic aorta.

1986 • 16 citations

Separation and characterization of macrophages and smooth muscle cells in rabbit atherosclerotic lesions.

1987 • 10 citations

Glutathione peroxidase in human and animal aortas.

1973 • 10 citations

Cell surface chemistry of arterial endothelium and blood monocytes in the normolipidemic rabbit.

1987 • 7 citations

Atherosclerosis in the Pediatric Age with Special Reference to Initiation, Progression and Regression of Atherosclerotic Lesions : Symposium on Atherosclerosis; Its Progression and Regression

1980 • 6 citations

Ultrastructural, Histochemical and Immunomorphologic Observations of Cholesterol-Induced Rabbit Aortic Lesion

1986 • 2 citations

Monocyte Migration Induced by Extracts of Aorta: Comparison between Normal Subjects and Familial Hypercholesterolemia

1987 • 1 citations