Gene Transfer of NAD(P)H Oxidase Inhibitor to the Vascular Adventitia Attenuates Medial Smooth Muscle Hypertrophy

Free radicals in biology and medicine

1991 • 17,840 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

2000 • 959 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O ₂ ⁻ and Systolic Blood Pressure in Mice

2001 • 598 citations

Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries

2002 • 589 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

1989 • 558 citations

Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

2000 • 467 citations

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

1997 • 463 citations

Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.

1991 • 397 citations

Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress

2000 • 385 citations

Role of NADPH Oxidase in the Vascular Hypertrophic and Oxidative Stress Response to Angiotensin II in Mice

2001 • 336 citations

Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

2002 • 282 citations

c-Src Induces Phosphorylation and Translocation of p47phox

2003 • 262 citations

Purification and Identification of Secreted Oxidative Stress-induced Factors from Vascular Smooth Muscle Cells

2000 • 259 citations

Expression of NADH/NADPH Oxidase p22 ^phox in Human Coronary Arteries

1999 • 259 citations

Angiotensin II Induces p67 ^phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts

1998 • 228 citations

Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats

1997 • 220 citations

NAD(P)H Oxidase Mediates Angiotensin II–Induced Vascular Macrophage Infiltration and Medial Hypertrophy

2003 • 181 citations

CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II–Induced Hypertension

2000 • 150 citations

Mitogen-Activated Protein/Extracellular Signal–Regulated Kinase Inhibition Attenuates Angiotensin II–Mediated Signaling and Contraction in Spontaneously Hypertensive Rat Vascular Smooth Muscle Cells

1999 • 146 citations

Novel NAD(P)H Oxidase Inhibitor Suppresses Angioplasty-Induced Superoxide and Neointimal Hyperplasia of Rat Carotid Artery

2003 • 142 citations

Increased NAD(P)H Oxidase and Reactive Oxygen Species in Coronary Arteries After Balloon Injury

2001 • 139 citations

Localization of angiotensinogen messenger RNA in rat aorta.

1988 • 136 citations

Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent Relaxation

2002 • 111 citations

Down-regulation of Platelet-derived Growth Factor Receptor Expression during Terminal Differentiation of 3T3-L1 Pre-adipocyte Fibroblasts

1996 • 48 citations

Isolation and Characterization of the Mouse PDGF β-Receptor Promoter

1995 • 43 citations

Pressure Mediates Angiotensin II–Induced Arterial Hypertrophy and PDGF-A Expression

1998 • 42 citations

Pressure but not angiotensin II-induced increases in wall mass or tone influences static and dynamic aortic mechanics

1999 • 9 citations