Structure and Function of ARF Proteins: Activators of Cholera Toxin and Critical Components of Intracellular Vesicular Transport Processes

Mechanisms of intracellular protein transport

1994 • 2,280 citations

COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

1994 • 1,294 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

1992 • 736 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles

1991 • 524 citations

ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes.

1992 • 464 citations

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein

1993 • 422 citations

Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

1994 • 418 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Multiple targets for brefeldin A

1991 • 347 citations

Adp-Ribosylating Toxins and G Proteins: Insights into Signal Transduction

1990 • 285 citations

Structure of the human ADP-ribosylation factor 1 complexed with GDP

1994 • 284 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport.

1992 • 259 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.

1993 • 228 citations

ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment.

1992 • 213 citations

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

1991 • 207 citations

Role of heterotrimeric G proteins in membrane traffic.

1992 • 206 citations

Fatty acyl-coenzyme a is required for budding of transport vesicles from Golgi cisternae

1989 • 204 citations

GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.

1994 • 192 citations

Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo

1994 • 190 citations

Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg 2+ Levels

1995 • 185 citations

Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion.

1992 • 185 citations

The arflike gene encodes an essential GTP-binding protein in Drosophila.

1991 • 148 citations

Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2

1991 • 144 citations

Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain.

1988 • 141 citations

Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes

1993 • 139 citations

Correlation between secretion and phospholipase D activation in differentiated HL60 cells

1993 • 129 citations

Two distinct populations of ARF bound to Golgi membranes.

1993 • 118 citations

A role for ADP-ribosylation factor in nuclear vesicle dynamics

1992 • 110 citations

An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes.

1994 • 109 citations

Different ARF Domains Are Required for the Activation of Cholera Toxin and Phospholipase D

1995 • 93 citations

Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.

1994 • 90 citations

ADP-ribosylation Factor-directed GTPase-activating Protein

1995 • 87 citations

Intravesicular acidification correlates with binding of ADP-ribosylation factor to microsomal membranes.

1992 • 83 citations

Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi

1993 • 63 citations

Mechanism of cholera toxin activation by a guanine nucleotide-dependent 19 kDa protein

1990 • 62 citations

Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae.

1994 • 59 citations

The amino terminus of ADP-ribosylation factor (ARF) 1 is essential for interaction with Gs and ARF GTPase-activating protein.

1994 • 57 citations

Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.

1994 • 51 citations

Effect of ADP-ribosylation factor amino-terminal deletions on its GTP-dependent stimulation of cholera toxin activity

1994 • 50 citations

The G protein-activating peptide, mastoparan, and the synthetic NH2-terminal ARF peptide, ARFp13, inhibit in vitro Golgi transport by irreversibly damaging membranes.

1994 • 44 citations

Influence of phospholipid asymmetry on fusion between large unilamellar vesicles

1992 • 42 citations

Characterization of class II and class III ADP-ribosylation factor genes and proteins in Drosophila melanogaster.

1994 • 32 citations

Diverse Biological Functions of Small GTP-binding Proteins in Yeast

1988 • 30 citations

ADP-ribosylation factors, 20,000 Mr guanine nucleotide-binding protein activators of cholera toxin and components of intracellular vesicular transport systems

1993 • 26 citations

ARF1(2–17) does not specifically interact with ARF1‐dependent pathways

1994 • 20 citations

Isolation of recombinant ADP-ribosylation factor 6, an approximately 20-kDa guanine nucleotide-binding protein, in an activated GTP-bound state.

1994 • 15 citations

Isolation of an amino-terminal deleted recombinant ADP-ribosylation factor 1 in an activated nucleotide-free state.

1995 • 14 citations