Apoptosis of CD4+CD25high T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer

2006 • 1,693 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors

2004 • 855 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

2006 • 443 citations

Sorafenib (BAY 43‐9006, Nexavar®), a Dual‐Action Inhibitor That Targets RAF/MEK/ERK Pathway in Tumor Cells and Tyrosine Kinases VEGFR/PDGFR in Tumor Vasculature

2006 • 422 citations

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans

2004 • 415 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

Impairment of CD4+CD25+ regulatory T-cells in autoimmune liver disease

2004 • 383 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

T regulatory cells in atopic dermatitis and subversion of their activity by superantigens

2004 • 307 citations

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer

2004 • 297 citations

Expression of FoxP3, a key molecule in CD4⁺CD25⁺ regulatory T cells, in adult T‐cell leukaemia/lymphoma cells

2004 • 276 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

2006 • 189 citations

The regulation of Foxp3 expression in regulatory CD4⁺CD25⁺T cells: Multiple pathways on the road

2007 • 161 citations

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

2005 • 141 citations

Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors

2003 • 117 citations

Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

2005 • 111 citations

BAY 43-9006: Early Clinical Data in Patients with Advanced Solid Malignancies

2002 • 101 citations

Influence of CD4+CD25+ Regulatory T Cells on Low/High-Avidity CD4+ T Cells following Peptide Vaccination

2006 • 58 citations

A study of the contrasting effects of cyclosporine, FK 506, and rapamycin on the suppression of allograft rejection.

1990 • 52 citations

Allosuppressive Donor CD4+CD25+ Regulatory T Cells Detach from the Graft and Circulate in Recipients after Liver Transplantation

2007 • 48 citations

CD4⁺regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis

2006 • 39 citations

Human Melanoma Cytolysis by Combined Inhibition of Mammalian Target of Rapamycin and Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor-2

2008 • 36 citations

Molecular targeting therapy for renal cell carcinoma

2006 • 27 citations

Ex vivo expansion of human CD4+CD25high regulatory T cells from transplant recipients permits functional analysis of small blood samples

2006 • 19 citations

Monitoring of Immunosuppressive Therapy in Renal Transplanted Patients

2004 • 7 citations