T cells in drug allergy

Danger signals: SOS to the immune system

2001 • 1,198 citations

Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin

1999 • 867 citations

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1935 • 697 citations

Acute generalized exanthematous pustulosis. Analysis of 63 cases

1991 • 522 citations

Acute Generalized Exanthematous Pustulosis

1991 • 425 citations

T-cell involvement in drug-induced acute generalized exanthematous pustulosis

2001 • 349 citations

Human Herpesvirus 6 Infection as a Risk Factor for the Development of Severe Drug-Induced Hypersensitivity Syndrome

1998 • 345 citations

Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis

2002 • 297 citations

Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils

1997 • 292 citations

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

1997 • 279 citations

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1998 • 269 citations

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

1998 • 238 citations

Allergic and autoimmune reactions to xenobiotics: how do they arise?

1998 • 233 citations

Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals

2000 • 212 citations

Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals.

1995 • 196 citations

T cell involvement in cutaneous drug eruptions

2001 • 191 citations

Infiltration of cytotoxic T cells in drug‐induced cutaneous eruptions

2000 • 185 citations

T cell immune responses to haptens. Structural models for allergic and autoimmune reactions

1996 • 175 citations

Sulfamethoxazole is metabolized to the hydroxylamine in humans

1992 • 172 citations

Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors

2000 • 166 citations

Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy

1997 • 166 citations

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

2000 • 155 citations

Molecular mechanisms of CD8+ T cell–mediated delayed hypersensitivity: Implications for allergies, asthma, and autoimmunity

1999 • 146 citations

T‐cell‐mediated cytotoxicity against keratinocytes in sulfamethoxazol‐induced skin reaction

1998 • 145 citations

Characterization of lidocaine-specific T cells.

1997 • 139 citations

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

2001 • 133 citations

Increased levels of interleukin 5 are associated with the generation of eosinophilia in drug-induced hypersensitivity syndrome

1998 • 131 citations

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions

2000 • 130 citations

Lymphocyte Activation in Cutaneous Drug Reactions

1995 • 106 citations

Role of T cells in drug allergies

1998 • 100 citations

CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes

2006 • 98 citations

Influence of reduced glutathione on the proliferative response of sulfamethoxazole‐specific and sulfamethoxazole‐metabolite‐specific human CD4+ T‐cells

2001 • 94 citations

T Cells Isolated from Positive Epicutaneous Test Reactions to Amoxicillin and Ceftriaxone are Drug Specific and Cytotoxic

2000 • 90 citations

RECENT ADVANCES IN THE PATHOLOGY OF CUTANEOUS DRUG ERUPTIONS

1999 • 84 citations

Role of Delayed Cellular Hypersensitivity and Adhesion Molecules in Amoxicillin-Induced Morbilliform Rashes

1997 • 78 citations

Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction

2000 • 77 citations

Expression of the skin‐homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneousallergic drug reactions

2000 • 77 citations

Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions.

1999 • 74 citations

Morbilliform Eruptions Caused by Penicillin**From the Departments of Dermatology and Cell. Biology, New York University School of Medicine, New York, New York.

1970 • 72 citations

Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones.

1999 • 71 citations

Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific alphabeta+ T cell clones

1998 • 68 citations

Highly Th2-Skewed Cytokine Profile of β-Lactam-Specific T Cells from Nonatopic Subjects with Adverse Drug Reactions

1999 • 67 citations

A New Chemical Aspect of Penicillin Allergy: The Direct Reaction of Penicillin with ɛ-Amino-Groups

1965 • 64 citations

Distinct Serum Cytokine Levels in Drug– and Measles–Induced Exanthema

1999 • 58 citations

Interaction of Sulfonamide Derivatives with the TCR of Sulfamethoxazole-Specific Human αβ+ T Cell Clones

1999 • 56 citations

Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection

1994 • 43 citations

Predictive drug allergy testing: an alternative viewpoint

2001 • 37 citations

Up-regulated perforin expression of CD8+ blood lymphocytes in generalized non-anaphylactic drug eruptions and exacerbated psoriasis.

2000 • 35 citations

Adverse cutaneous drug reactions in patients with human immunodeficiency virus-1 infection

2000 • 35 citations

Adverse Drug Reactions in Sjögren's Syndrome: Frequent allergic reactions and a specific trimethoprim-associated systemic reaction

1999 • 32 citations

Molecular Basis of Drug Recognition by Specific T–Cell Receptors

1999 • 30 citations