Downregulation of estrogen‐metabolizing 17β‐hydroxysteroid dehydrogenase Type 2 expression correlates inversely with Ki67 proliferation marker in colon‐cancer development
Data up to Jan 2025
Total Citations Per Year
Abstract
References (57)
Molecular cloning: A laboratory manual
1990 • 85,659 citations
Genetic Alterations during Colorectal-Tumor Development
1988 • 6,691 citations
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
1981 • 3,794 citations
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
1983 • 3,602 citations
Phyto-oestrogens and Western Diseases
1997 • 1,280 citations
Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1
1997 • 1,098 citations
SPECIFIC STAINING OF SULPHATE GROUPS WITH ALCIAN BLUE AT LOW pH
1964 • 917 citations
Mechanisms of Tumor Progression
2010 • 608 citations
Human Estrogen Receptor -Gene Structure, Chromosomal Localization, and Expression Pattern
1997 • 576 citations
Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer
1985 • 479 citations
Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
1993 • 433 citations
Molecular Endocrinology of Hydroxysteroid Dehydrogenases*
1997 • 409 citations
Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects.
1988 • 380 citations
Estrogen Replacement Therapy and Risk of Fatal Colon Cancer in a Prospective Cohort of Postmenopausal Women
1995 • 364 citations
Phytoestrogens1
1998 • 360 citations
Selective loss of estrogen receptor beta in malignant human colon.
2000 • 313 citations
Complete amino acid sequence of human placental 17β‐hydroxysteroid dehydrogenase deduced from cDNA
1988 • 298 citations
17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
1999 • 297 citations
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
2000 • 274 citations
Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: Relationship to carcinogenicity
1997 • 274 citations
Fundamental principles of in situ hybridization.
1993 • 242 citations
Postmenopausal Hormone Use and Risk of Large-Bowel Cancer
1995 • 235 citations
Molecular Endocrinology of Hydroxysteroid Dehydrogenases
1997 • 212 citations
17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.
1994 • 209 citations
Histological Typing of Intestinal Tumours
1978 • 204 citations
Inactivation of the Peroxisomal Multifunctional Protein-2 in Mice Impedes the Degradation of Not Only 2-Methyl-branched Fatty Acids and Bile Acid Intermediates but Also of Very Long Chain Fatty Acids
2000 • 192 citations
Human 17 β-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression
1996 • 187 citations
Large Bowel Cancer in Women in Relation to Reproductive and Hormonal Factors: A Case-Control Study<xref ref-type="fn" rid="FN2">2</xref>
1983 • 179 citations
Phytoestrogens
1998 • 173 citations
Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.
1996 • 171 citations
Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases
1997 • 155 citations
Differential expression patterns of the PEA3 group transcription factors through murine embryonic development
1997 • 147 citations
The presence of functional estrogen receptors in intestinal epithelial cells.
1993 • 132 citations
Reproductive factors and colon cancers
1990 • 128 citations
Functional Estrogen Receptor β in Colon Cancer Cells
1999 • 122 citations
Colorectal mucin histochemistry in health and disease: A critical review
1994 • 110 citations
Peroxisomal Bifunctional Protein Deficiency Revisited: Resolution of Its True Enzymatic and Molecular Basis
1999 • 103 citations
Human 17β-Hydroxysteroid Dehydrogenase Type 2 Messenger Ribonucleic Acid Expression and Localization in Term Placenta and in Endometrium during the Menstrual Cycle1
1998 • 85 citations
Aberrant accumulation of p53 associates with Ki67 and mitotic count in benign skin lesions
2006 • 78 citations
Loss of Estrogen Inactivation in Colonic Cancer
1999 • 74 citations
Expression of 17β-hydroxysteroid dehydrogenase in human granulosa cells: correlation with follicular size, cytochrome P450 aromatase activity and oestradiol production
1994 • 67 citations
17β‐hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue
1999 • 63 citations
Estrogen receptor-mediated direct stimulation of colon cancer cell growth in vitro
1994 • 60 citations
Mouse 17 beta-hydroxysteroid dehydrogenase type 2 mRNA is predominantly expressed in hepatocytes and in surface epithelial cells of the gastrointestinal and urinary tracts
1998 • 57 citations
Colonic mucin glycoproteins in health and disease.
1986 • 54 citations
Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum*
1999 • 53 citations
Oestrogen inactivation in the colon: analysis of the expression and regulation of 17 β -hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer
2000 • 43 citations
REVIEW ARTICLE. MUCUS GLYCOPROTEINS AND THEIR ROLE IN COLORECTAL DISEASE
1996 • 40 citations
17β-Hydroxysteroid Dehydrogenase Type 1 and 2 Expression in the Human Fetus1
2000 • 38 citations
Thapsigargin-Induced Gene Expression in Nonexcitable Cells Is Dependent on Calcium Influx
1997 • 34 citations
Principles of Pharmacology: Basic Concepts and Clinical Applications
1997 • 29 citations
Immunohistochemical Assessment of Growth Fractions in Colorectal Adenocarcinomas with Monoclonal Antibody Ki-67
1990 • 24 citations
Characterization of 17β-hydroxysteroid dehydrogenase type 1 in choriocarcinoma cells: regulation by basic fibroblast growth factor
1994 • 21 citations
Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17 -Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum
1999 • 17 citations
17 -Hydroxysteroid Dehydrogenase Type 1 and 2 Expression in the Human Fetus
2000 • 13 citations
Much histochemistry in colonic polyps and cancer
1987 • 10 citations
Colonic Mucin-Carbohydrate Components in Colorectal Tumors and Their Possible Relationship to MUC2, p53 and DCC Immunoreactivities
2000 • 10 citations