Upregulation of enzymatic activity by interleukin-1 in osteoarthritis

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Biology of interleukin 1

1988 • 1,547 citations

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.

1989 • 604 citations

Structure and biology of cartilage and bone matrix noncollagenous macromolecules

1989 • 565 citations

Articular Cartilage Biochemistry

1987 • 504 citations

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

1986 • 496 citations

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.

1994 • 444 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

1990 • 361 citations

Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA.

1996 • 212 citations

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.

1992 • 208 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.

1996 • 151 citations

Biological Regulation of the Chondrocytes

2022 • 139 citations

Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis

1990 • 128 citations

The superficial layer of human articular cartilage is more susceptible to interleukin‐1–induced damage than the deeper layers

1996 • 127 citations

Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin b and an inhibitor of matrix metalloproteinases. evidence for two converging pathways of chondrocyte‐mediated proteoglycan degradation

1993 • 123 citations

Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.

1996 • 119 citations

Expression of IL-1 genes in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation

1986 • 113 citations

Interleukin‐1‐Induced Prostaglandin E₂ Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A₂ and Cyclooxygenase‐2

1994 • 108 citations

Direct Evidence for Active Metalloproteinases Mediating Matrix Degradation in Interleukin 1-Stimulated Human Articular Cartilage

1993 • 98 citations

In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1.

1991 • 89 citations

In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage.

1991 • 76 citations

Interleukin-1-Induced Prostaglandin E2 Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A2 and Cyclooxygenase-2

1994 • 76 citations

Production of cytokines by chondrocytes and its role in proteoglycan degradation.

1991 • 75 citations

Modulation of the catabolic effects of interleukin-1β on human articular chondrocytes by transforming growth factor-β

1996 • 59 citations

Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor α and interleukin‐1

1993 • 57 citations

Some recombinant human cytokines stimulate glycosaminoglycan synthesis in human synovial fibroblast cultures and inhibit it in human articular cartilage cultures

1989 • 56 citations

src‐related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP‐1, in interleukin‐1‐stimulated synovial fibroblasts

1996 • 47 citations

Interactions between interleukin‐1 and basic fibroblast growth factor on articular chondrocytes. Effects on cell growth, prostanoid production, and receptor modulation

1991 • 27 citations

Chronic inflammatory joint diseases: natural inhibitors of interleukin 1 and tumor necrosis factor alpha.

1991 • 21 citations

The effect of interleukin-1 on cytokine gene expression in cultured human articular chondrocytes analyzed by messenger rna phenotyping

1993 • 21 citations