Association between Receptor Protein-tyrosine Phosphatase RPTPα and the Grb2 Adaptor

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

1992 • 335 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

1995 • 257 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

SH3 Domain-mediated Interaction of Dystroglycan and Grb2

1995 • 247 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

1993 • 237 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Crystal Structure of the Mammalian Grb2 Adaptor

1995 • 202 citations

‘Zip codes’ direct intracellular protein tyrosine phosphatases to the correct cellular ‘address’

1994 • 201 citations

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

1994 • 192 citations

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.

1990 • 191 citations

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

1994 • 182 citations

Cloning and expression of a widely expressed receptor tyrosine phosphatase.

1990 • 180 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

1994 • 160 citations

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

1990 • 150 citations

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain.

1990 • 149 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

1994 • 132 citations

The Grb2 adaptor

1995 • 127 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.

1994 • 125 citations

The receptor-like protein tyrosine phosphatase HPTP alpha has two active catalytic domains with distinct substrate specificities.

1991 • 121 citations

Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact.

1995 • 121 citations

Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells

1995 • 114 citations

Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

1994 • 112 citations

Mitogen-Activated Protein Kinase Activation Is Insufficient for Growth Factor Receptor-Mediated PC12 Cell Differentiation

1995 • 107 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.

1991 • 90 citations

Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.

1996 • 87 citations

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.

1994 • 85 citations

Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.

1994 • 77 citations

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

1994 • 75 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

Regulation of the Src protein tyrosine kinase

1995 • 69 citations

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

1995 • 68 citations

Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.

1995 • 65 citations

Multiple forms of the human tyrosine phosphatase RPTP alpha. Isozymes and differences in glycosylation.

1994 • 55 citations

Tyrosine Phosphorylation of BCR by FPS/FES Protein-Tyrosine Kinases Induces Association of BCR with GRB-2/SOS

1995 • 51 citations

<scp>l</scp>-Histidinol Provides Effective Selection of Retrovirus-Vector-Transduced Keratinocytes Without Impairing Their Proliferative Potential

1991 • 47 citations

pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation.

1992 • 31 citations

The effects of v-src expression on the differentiation of embryonal carcinoma cells.

1988 • 29 citations

Protein tyrosine phosphatases: from structure to function

1994 • 23 citations

Platelet-derived growth factor stimulates phosphorylation of growth factor receptor-binding protein-2 in vascular smooth muscle cells.

1994 • 16 citations