Sequence and functional relationships between androgen-binding protein/sex hormone-binding globulin and its homologs protein S, Gas6, laminin, and agrin

Basic local alignment search tool

1990 • 87,358 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Structure and biological activity of basement membrane proteins

1989 • 967 citations

Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

1996 • 915 citations

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

1996 • 881 citations

Structure and function of laminin: anatomy of a multidomain glycoprotein

1990 • 812 citations

A new nomenclature for the laminins

1994 • 753 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

1995 • 704 citations

Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding

1987 • 677 citations

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia

1990 • 669 citations

Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

1992 • 669 citations

Agrin Acts via a MuSK Receptor Complex

1996 • 653 citations

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

1993 • 589 citations

The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*

1990 • 559 citations

Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor

1994 • 509 citations

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

1990 • 499 citations

Role of laminin a chain in the development of epithelial cell polarity

1988 • 488 citations

Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains.

1988 • 486 citations

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

1995 • 468 citations

Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons

1995 • 446 citations

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

1991 • 446 citations

Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

1990 • 405 citations

Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting site.

1986 • 318 citations

Structure and expression of a rat agrin

1991 • 310 citations

Basement membrane glycoprotein laminin binds to heparin

1980 • 286 citations

Laminin-binding protein 120 from brain is closely related to the dystrophin-associated glycoprotein, dystroglycan, and binds with high affinity to the major heparin binding domain of laminin

1993 • 282 citations

Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity.

1985 • 264 citations

The cellular interactions of laminin fragments. Cell adhesion correlates with two fragment-specific high affinity binding sites.

1987 • 243 citations

Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

1992 • 241 citations

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.

1995 • 232 citations

Alternative Splicing of Agrin Alters Its Binding to Heparin, Dystroglycan, and the Putative Agrin Receptor

1996 • 223 citations

Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen

1986 • 216 citations

A High-Affinity Androgen-Binding Protein (ABP) in Rat Testis: Evidence for Secretion into Efferent Duct Fluid and Absorption by Epididymis1

1973 • 212 citations

Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3

1995 • 212 citations

RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes

1992 • 212 citations

Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.

1986 • 204 citations

Structure, Function, and Regulation of Androgen-Binding Protein/Sex Hormone-Binding Globulin

1994 • 201 citations

Potential functions of plasma steroid-binding proteins

1995 • 196 citations

Characterization of Gas6, a Member of the Superfamily of G Domain-containing Proteins, as a Ligand for Rse and Axl

1996 • 195 citations

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen.

1990 • 191 citations

Developmental regulation of highly active alternatively spliced forms of agrin

1993 • 188 citations

Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells.

1992 • 184 citations

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin.

1993 • 180 citations

Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production.

1990 • 178 citations

Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils.

1990 • 151 citations

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.

1991 • 150 citations

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.

1993 • 148 citations

Testosterone-estradiol-binding globulin binds to human prostatic cell membranes

1985 • 146 citations

Organization of the human protein S genes

1990 • 143 citations

A recognition system for sex-hormone-binding protein-estradiol complex in human decidual endometrium plasma membranes

1984 • 143 citations

Demonstration of Androgen-Binding Components in Rat Epididymis Cytosol and Comparison with Binding Components in Prostate and Other Tissues1

1971 • 140 citations

Estradiol causes the rapid accumulation of cAMP in human prostate.

1994 • 136 citations

A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the alpha 3 beta 1 integrin

1992 • 135 citations

The Human Sex Hormone-Binding Globulin Gene Contains Exons for Androgen-Binding Protein and Two Other Testicular Messenger RNAs

1989 • 134 citations

Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts.

1992 • 130 citations

Sertoli cell origin of testicular androgen-binding protein (ABP)

1975 • 129 citations

Biologically Active Steroids Activate Receptor-Bound Human Sex Hormone-Binding Globulin to Cause LNCaP Cells to Accumulate Adenosine 3′,5′-Monophosphate*

1990 • 129 citations

Primary structure of bovine vitamin K-dependent protein S.

1986 • 126 citations

Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A

1996 • 123 citations

Functions of agrin and agrin-related proteins

1993 • 119 citations

The RGD containing site of the mouse laminin A chain is active for cell attachment, spreading, migration and neurite outgrowth

1991 • 118 citations

Solubilization and Partial Characterization of the Sex Hormone-binding Globulin Receptor from Human Prostate

1989 • 118 citations

The core protein of the matrix-associated heparan sulfate proteoglycan binds to fibronectin.

1990 • 118 citations

SECRETION OF TESTOSTERONE-ESTRADIOL-BINDING GLOBULIN BY A HUMAN HEPATOMA-DERIVED CELL LINE

1981 • 115 citations

Agrin mediates cell contact-induced acetylcholine receptor clustering

1991 • 113 citations

Amino acid sequence of the sex steroid binding protein of human blood plasma

1986 • 112 citations

Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies.

1990 • 112 citations

Rapsyn Clusters and Activates the Synapse-Specific Receptor Tyrosine Kinase MuSK

1996 • 110 citations

The Laminins: A Family of Basement Membrane Glycoproteins Important in Cell Differentiation and Tumor Metastases

1993 • 105 citations

Localization of three distinct heparin-binding domains of laminin by monoclonal antibodies.

1988 • 104 citations

Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing.

1991 • 101 citations

Self-assembly of a high molecular weight basement membrane heparan sulfate proteoglycan into dimers and oligomers.

1987 • 101 citations

Sex hormone‐binding globulin, androgen‐binding protein, and vitamin K‐dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein

1992 • 97 citations

Cloning and characterization of human liver cDNA encoding a protein S precursor.

1987 • 97 citations

Electrophoretic Evidence for the Presence of an Estrogen-Binding β-Globulin in Human Plasma

1966 • 97 citations

Prevention of growth arrest‐induced cell death of vascular smooth muscle cells by a product of growth arrest‐specific gene, gas6

1996 • 96 citations

Adhesion molecules of the nervous system

1993 • 96 citations

Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin

1997 • 93 citations

Sex hormone-binding globulin: Anatomy and physiology of a new regulatory system

1991 • 92 citations

Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit.

1991 • 91 citations

Stimulation of prostate cancer growth by androgens and estrogens through the intermediacy of sex hormone-binding globulin.

1996 • 90 citations

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

1990 • 89 citations

Rat androgen-binding protein: evidence for identical subunits and amino acid sequence homology with human sex hormone-binding globulin.

1987 • 85 citations

Intron-exon organization of the active human protein S gene PS.alpha. and its pseudogene PS.beta.: Duplication and silencing during primate evolution

1990 • 85 citations

A novel laminin E8 cell adhesion site required for lung alveolar formation in vitro

1994 • 84 citations

Structural study of long arm fragments of laminin

1988 • 82 citations

Agrin Binding to α-Dystroglycan

1996 • 81 citations

Selective uptake and metabolism of androgens by rat epididymis. The presence of a cytoplasmic receptor

1971 • 78 citations

Androgen-binding protein. Purification from rat epididymis, characterization, and immunocytochemical localization.

1981 • 77 citations

Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A.

1996 • 77 citations

Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells.

1989 • 75 citations

Laminin binding proteins

1991 • 72 citations

Inhibition of laminin self-assembly and interaction with type IV collagen by antibodies to the terminal domain of the long arm.

1986 • 70 citations

Identification of a Cell Surface-binding Protein for the Core Protein of the Basement Membrane Proteoglycan

1989 • 70 citations

Electron Microscope Radioautographic Evidence ofin VivoAndrogen-Binding Protein Internalization in the Rat Epididymis Principal Cells*

1988 • 65 citations

The Androgen-Binding Protein Gene Is Expressed in Male and Female Rat Brain*

1990 • 65 citations

Vitamin K-dependent protein S is similar to rat androgen-binding protein

1987 • 65 citations

Interaction of sex hormone-binding globulin with plasma membranes from the rat epididymis and other tissues

1994 • 62 citations

There are two forms of androgen binding protein in human testes. Comparison of their protomeric variants with serum testosterone-estradiol binding globulin.

1985 • 62 citations

Sex Hormone‐Binding Globulin Binding to Cell Membranes and Generation of a Second Messenger

1992 • 62 citations

Biological Effects of Sex Hormone-Binding Globulin on Androgen-Induced Proliferation and Androgen Metabolism in LNCaP Prostate Cells*

1991 • 62 citations

Dystrophin-associated proteins and synapse formation: Is α-dystroglycan the agrin receptor?

1994 • 60 citations

Overexpression of Androgen-Binding Protein/Sex Hormone-Binding Globulin in Male Transgenic Mice: Tissue Distribution and Phenotypic Disorders1

1997 • 58 citations

Sulfatide-binding domain of the laminin A chain.

1990 • 58 citations

Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin.

1990 • 57 citations

Spermatogenic cells do internalize Sertoli androgen-binding protein: a transmission electron microscopy autoradiographic study in the rat.

1994 • 54 citations

Secretion and role of androgen-binding proteins in the testis and epididymis.

1976 • 53 citations

Amino acid sequence and distribution of mRNA encoding a major skeletal muscle laminin binding protein: an extracellular matrix-associated protein with an unusual COOH-terminal polyaspartate domain.

1988 • 53 citations

Characterization of a synthetic peptide that inhibits the interaction between protein S and C4b-binding protein

1989 • 51 citations

Biological relevance of the interaction between sex steroid binding protein and its specific receptor of MCF-7 cells: Effect on the estradiol-induced cell proliferation

1993 • 50 citations

Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts

1992 • 49 citations

Binding of an extracellular steroid-binding globulin to membranes and soluble receptors from human breast cancer cells (MCF-7 cells).

1992 • 49 citations

Testing the Agrin Hypothesis

1996 • 48 citations

Receptor-Mediated Endocytosis of an Extracellular Steroid-Binding Protein (TeBG) in MCF-7 Human Breast Cancer Cells*

1991 • 48 citations

Steroid-Binding and Dimerization Domains of Human Sex Hormone-Binding Globulin Partially Overlap: Steroids and Ca2+ Stabilize Dimer Formation

1994 • 48 citations

Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3.

1996 • 47 citations

Selective removal of glycosylation sites from sex hormone-binding globulin by site-directed mutagenesis.

1992 • 47 citations

Immunocytochemical localization of 4-ene steroid 5 alpha-reductase type 1 along the rat epididymis during postnatal development.

1994 • 47 citations

Isolation and characterization of a laminin-binding protein from rat and chick muscle.

1988 • 46 citations

Binding of protein S to C4b-binding protein. Mutagenesis of protein S.

1992 • 42 citations

The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system

1991 • 42 citations

The plasma membrane of epididymal epithelial cells has a specific receptor which binds to androgen-binding protein and sex steroid-binding protein

1992 • 42 citations

Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function.

1993 • 40 citations

A Novel Recognition Site on Laminin for the α3β1 Integrin

1996 • 40 citations

Characterization of Met-139 as the photolabeled amino acid residue in the steroid binding site of sex hormone binding globulin using .DELTA.6 derivatives of either testosterone or estradiol as unsubstituted photoaffinity labeling reagents

1992 • 39 citations

Tissue Uptake of Human Sex Hormone-Binding Globulin and its Influence on Ligand Kinetics in the Adult Female Rat1

1992 • 39 citations

Human Testicular Androgen-Binding Protein Shares Immunodeterminants with Serum Testosterone-Estradiol-Binding Globulin^*

1984 • 37 citations

Distribution of immunoreactive androgen-binding protein/sex hormone-binding globulin in tissues of the fetal rat

1996 • 36 citations

The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis.

1996 • 35 citations

Binding of sex-hormone-binding globulin (SHBG) to testicular membranes and solubilized receptors

1992 • 32 citations

Identification of receptors binding fibronectin and laminin on fetal rat lung cells

1996 • 32 citations

Studies of the Interaction between Human Protein S and Human C4b-Binding Protein Using Deletion Variants of Recombinant Human Protein S

1994 • 29 citations

Binding of an extracellular steroid-binding globulin to membranes and soluble receptors from human breast cancer cells (MCF-7 cells)

1992 • 29 citations

Stimulation of prostate cancer growth by androgens and estrogens through the intermediacy of sex hormone-binding globulin

1996 • 28 citations

Evidence for a protein S receptor(s) on human vascular smooth muscle cells. Analysis of the binding characteristics and mitogenic properties of protein S on human vascular smooth muscle cells

1995 • 28 citations

Spermatogenic cells do internalize Sertoli androgen-binding protein: a transmission electron microscopy autoradiographic study in the rat

1994 • 27 citations

Photoaffinity labelled rat androgen-binding protein and human sex hormone steroid-binding protein bind specifically to rat germ cells

1992 • 26 citations

The alternate N-terminal sequence of rat androgen-binding protein/sex hormone-binding globulin contains a nuclear targeting signal.

1996 • 24 citations

Structure/function analyses of human sex hormone‐binding globulin by site‐directed mutagenesis

1992 • 24 citations

Laminin and fibronectin increase the steady state level of the 67 kD high affinity metastasis-associated laminin receptor mRNA in human cancer cells

1990 • 24 citations

Selective removal of glycosylation sites from sex hormone-binding globulin by site-directed mutagenesis

1992 • 22 citations

Analysis of the Steroid Binding Domain of Rat Androgen-Binding Protein*

1991 • 21 citations

Immunocytochemical localization of 4-ene steroid 5 alpha-reductase type 1 along the rat epididymis during postnatal development

1994 • 20 citations

Characterization of a high‐affinity and specific binding site for Gas6

1996 • 20 citations

The receptor for human sex steroid binding protein (SBP) is expressed on membranes of neoplastic endometrium

1992 • 20 citations

Steroid-protein interactions II—Monographs in endocrinology

1986 • 19 citations

Immunological cross reactivity between testicular androgen-binding protein and serum testosterone-binding globulin

1975 • 19 citations

Localization of the 110 kDa receptor for laminin in brains of embryonic and postnatal mice

1995 • 19 citations

Internalization of human sex steroid-binding protein in the monkey epididymis

1990 • 18 citations

Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function

1993 • 18 citations

Subunit Structure of Sex-Steroid-Binding Plasma Proteins from Man, Cattle, Dog, and Rabbit

1984 • 17 citations

Mutagenesis of essential functional residues of rat androgen-binding protein/sex hormone-binding globulin.

1993 • 15 citations

A Mr 80K hepatocyte surface protein(s) interacts with basement membrane components

1990 • 15 citations

The genes for SHBG/ABP and the SHBG-like region of vitamin K-dependent protein S have evolved from a common ancestral gene

1991 • 15 citations

The alternate N-terminal sequence of rat androgen-binding protein/sex hormone-binding globulin contains a nuclear targeting signal

1996 • 14 citations

Mutagenesis of essential functional residues of rat androgen-binding protein/sex hormone-binding globulin

1993 • 11 citations

Comparison of rabbit androgen binding protein with testosterone estradiol binding globulin—I. Physical and chemical properties

1984 • 10 citations

The role of asparagine-linked oligosaccharides in the subunit structure, steroid binding, and secretion of androgen-binding protein.

1992 • 10 citations

Promotion of human oral squamous cell carcinoma adhesion in vitro by the carboxy-terminal globular domain of laminin

1994 • 9 citations

The role of asparagine-linked oligosaccharides in the subunit structure, steroid binding, and secretion of androgen-binding protein

1992 • 6 citations

Structure of the Rat Androgen‐Binding Protein Genea

1988 • 2 citations

Laminin “A” chain fragment of MR 43 kilodalton contains PC12 cell attachment promoting site

1990 • 1 citations