Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

1996 • 881 citations

Synaptic structure and development: The neuromuscular junction

1993 • 846 citations

The Agrin Hypothesis

1990 • 637 citations

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice

1995 • 530 citations

Motor Nerve Sprouting

1981 • 525 citations

Identification of agrin, a synaptic organizing protein from Torpedo electric organ.

1987 • 467 citations

Nerve‐induced and spontaneous redistribution of acetylcholine receptors on cultured muscle cells.

1977 • 459 citations

Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin β2

1995 • 447 citations

Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses.

1979 • 348 citations

Concentration of acetylcholine receptor mRNA in synaptic regions of adult muscle fibres

1985 • 344 citations

Structure and expression of a rat agrin

1991 • 310 citations

The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans

1993 • 305 citations

Agrin Is a Heparan Sulfate Proteoglycan

1995 • 281 citations

Dystroglycan binds nerve and muscle agrin

1994 • 272 citations

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

1992 • 252 citations

Components of Torpedo electric organ and muscle that cause aggregation of acetylcholine receptors on cultured muscle cells.

1984 • 251 citations

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.

1995 • 232 citations

Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

1992 • 231 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes

1992 • 212 citations

cDNA that encodes active agrin

1992 • 199 citations

Developmental regulation of highly active alternatively spliced forms of agrin

1993 • 188 citations

The Role of Agrin in Synapse Formation

1995 • 181 citations

Selective expression of an acetylcholine receptor–lacZ transgene in synaptic nuclei of adult muscle fibers

1991 • 178 citations

Neuregulins and their receptors

1995 • 178 citations

Synapse-Associated Expression of an Acetylcholine Receptor-Inducing Protein, ARIA/Heregulin, and Its Putative Receptors, ErbB2 and ErbB3, in Developing Mammalian Muscle

1995 • 170 citations

Agrin-induced specializations contain cytoplasmic, membrane, and extracellular matrix-associated components of the postsynaptic apparatus

1989 • 163 citations

Molecular events in synaptogenesis: nerve-muscle adhesion and postsynaptic differentiation

1988 • 140 citations

Motor neurons contain agrin-like molecules.

1988 • 131 citations

Agrin is a differentiation-inducing “stop signal” for motoneurons in vitro

1995 • 120 citations

Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor

1991 • 116 citations

Structure and chromosomal localization of the mammalian agrin gene

1992 • 115 citations

Agrin-related molecules are concentrated at acetylcholine receptor clusters in normal and aneural developing muscle.

1989 • 104 citations

The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells

1995 • 101 citations

43K Protein and Acetylcholine Receptors Colocalize during the Initial Stages of Neuromuscular Synapse Formation in Vivo

1993 • 91 citations

Formation of postsynaptic specializations induced by latex beads in cultured muscle cells

1982 • 82 citations

Redistribution of acetylcholine receptors on developing rat myotubes

1984 • 81 citations

N-CAM, 43K-Rapsyn, and S-Laminin mRNAs Are Concentrated at Synaptic Sites in Muscle Fibers

1995 • 81 citations

Role for a synapse-specific carbohydrate in agrin-induced clustering of acetylcholine receptors

1995 • 80 citations

Embryonic growth and innervation of rat skeletal muscles. - III. Neural regulation of junctional and extra-junctional acetylcholine receptor clusters

1981 • 79 citations

Early appearance of and neuronal contribution to agrin-like molecules at embryonic frog nerve-muscle synapses formed in culture

1992 • 77 citations

Progressive restriction of synaptic vesicle protein to the nerve terminal during development of the neuromuscular junction

1989 • 74 citations

Cell-specific regulation of agrin RNA splicing in the chick ciliary ganglion

1994 • 74 citations

The Formation of Neuromuscular Synapses

1976 • 68 citations

Distribution of agrin mRNAs in the chick embryo nervous system

1994 • 65 citations

Analysis of proteoglycan expression in developing chicken brain: Characterization of a heparan sulfate proteoglycan that interacts with the neural cell adhesion molecule

1995 • 64 citations

Comparison of agrin-like proteins from the extracellular matrix of chicken kidney and muscle with neural agrin, a synapse organizing protein

1991 • 60 citations

Isolation and characterization of a cDNA that encodes an agrin homolog in the marine ray

1992 • 56 citations

Nerve disperses preexisting acetylcholine receptor clusters prior to induction of receptor accumulation in Xenopus muscle cultures

1984 • 55 citations

Localization of acetylcholine receptors and cholinesterase on nerve- contacted and noncontacted muscle cells grown in the presence of agents that block action potentials

1986 • 31 citations

Neuromuscular development following tetrodotoxin‐induced inactivity in mouse embryos

1990 • 25 citations