The stem-cell menagerie

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

1999 • 1,872 citations

Direct isolation of human central nervous system stem cells

2000 • 1,822 citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 • 1,721 citations

A Stem Cell Molecular Signature

2002 • 1,553 citations

Changing potency by spontaneous fusion

2002 • 1,525 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell

1996 • 1,366 citations

Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage

2000 • 1,108 citations

EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells

2002 • 1,030 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations

2001 • 928 citations

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

1987 • 881 citations

Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells

2000 • 869 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

Identification of major cell classes in the developing mammalian nervous system

1985 • 803 citations

Characterization of CNS Precursor Subtypes and Radial Glia

2001 • 739 citations

Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain

2000 • 716 citations

A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes

1979 • 676 citations

Purification of a pluripotent neural stem cell from the adult mouse brain

2001 • 667 citations

LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal

2002 • 662 citations

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells

1993 • 651 citations

Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia

2002 • 607 citations

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

1998 • 593 citations

Proliferation and differentiation of rat neuroepithelial precursor cells in vivo

1988 • 563 citations

Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages

1999 • 551 citations

Mouse-Musashi-1, a Neural RNA-Binding Protein Highly Enriched in the Mammalian CNS Stem Cell

1996 • 534 citations

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

1999 • 534 citations

Adult Mammalian Forebrain Ependymal and Subependymal Cells Demonstrate Proliferative Potential, but only Subependymal Cells Have Neural Stem Cell Characteristics

1999 • 530 citations

Adult neurogenesis and neural stem cells of the central nervous system in mammals

2002 • 529 citations

A comparison of the properties ofSox-3withSryand two related genes,Sox-1andSox-2

1996 • 485 citations

Architecture and cell types of the adult subventricular zone: In search of the stem cells

1998 • 484 citations

Sox genes find their feet

1997 • 478 citations

A role for SOX1 in neural determination

1998 • 470 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells

2002 • 444 citations

Stem cells in the adult mammalian central nervous system

1999 • 439 citations

Identification of radial glial cells within the developing murine central nervous system: studies based upon a new immunohistochemical marker

1988 • 428 citations

Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex

2000 • 419 citations

Neural Stem Cells in the Adult Human Brain

1999 • 418 citations

Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis

1981 • 397 citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1999 • 397 citations

The origin and migration of cortical neurones: new vistas

2000 • 392 citations

Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice

2000 • 379 citations

Sox2 regulatory sequences direct expression of a β-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells

2000 • 351 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres

2002 • 337 citations

Assessment of aldehyde dehydrogenase in viable cells

1995 • 322 citations

The bHLH GeneHes1as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 311 citations

Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cells: an ultrastructural analysis of clonally related cells

1993 • 311 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells

1990 • 300 citations

Stem Cells and Pattern Formation in the Nervous System

2001 • 298 citations

Neuroepithelial Stem Cells from the Embryonic Spinal Cord: Isolation, Characterization, and Clonal Analysis

1997 • 298 citations

From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs

2001 • 298 citations

Multipotent and restricted precursors in the central nervous system

1999 • 269 citations

Expression of Neural RNA-Binding Proteins in the Postnatal CNS: Implications of Their Roles in Neuronal and Glial Cell Development

1997 • 256 citations

Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF

1995 • 238 citations

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain

2002 • 232 citations

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

2001 • 229 citations

Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene.

2001 • 198 citations

Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone

2000 • 191 citations

Chapter 1 The subventricular zone: source of neuronal precursors for brain repair

2000 • 187 citations

Properties of a Fetal Multipotent Neural Stem Cell (NEP Cell)

2002 • 183 citations

Lack of Replicative Senescence in Normal Rodent Glia

2001 • 182 citations

Multipotential and lineage restricted precursors coexist in the mammalian perinatal subventricular zone

1997 • 170 citations

Generation of Dopaminergic Neurons in the Adult Brain from Mesencephalic Precursor Cells Labeled with anestin-GFPTransgene

2001 • 161 citations

POU transcription factors control expression of CNS stem cell-specific genes

1998 • 158 citations

Prospective Cell Sorting of Embryonic Rat Neural Stem Cells and Neuronal and Glial Progenitors Reveals Selective Effects of Basic Fibroblast Growth Factor and Epidermal Growth Factor on Self-Renewal and Differentiation

2003 • 152 citations

Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor

1998 • 143 citations

Differential regulation of telomerase activity and TERT expression during brain development in mice

2001 • 141 citations

Flow cytometric analysis of neural stem cells in the developing and adult mouse brain

2002 • 122 citations

Regeneration and Proliferation of Embryonic and Adult Rat Hippocampal Neurons in Culture

1999 • 114 citations

Cellular Characterization of Epidermal Growth Factor-expanded Free-floating Neurospheres

2003 • 103 citations

Characterization of neurosphere cell phenotypes by flow cytometry

2000 • 95 citations

Microarray analysis of selected genes in neural stem and progenitor cells

2002 • 94 citations

A nestin-negative precursor cell from the adult mouse brain gives rise to neurons and glia

1997 • 88 citations

Identification of Two Distinct Types of Multipotent Neural Precursors That Appear Sequentially during CNS Development

2001 • 73 citations

Roles of cell-autonomous mechanisms for differential expression of regionspecific transcription factors in neuroepithelial cells

1996 • 63 citations

Modeling Stem Cell Development by Retrospective Analysis of Gene Expression Profiles in Single Progenitor‐Derived Colonies

2002 • 49 citations

Neural Stem Cells: Plasticity and Their Transdifferentiation Potential

2002 • 48 citations

Isolation of a glial‐restricted tripotential cell line from embryonic spinal cord cultures

2002 • 46 citations

EGF‐responsive neural stem cells are a transient population in the developing mouse spinal cord

2001 • 41 citations

Mechanisms of Progenitor Maturation Are Conserved in the Striatum and Cortex

2000 • 38 citations

Correlates between Hematopoiesis and Neuropoiesis: Neural Stem Cells

1999 • 17 citations

Precursor cell types in the germinal zone of the cerebral cortex

1995 • 16 citations

Transdifferentiation of Neural Stem Cells, or Not?

2002 • 9 citations