Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree
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References (73)
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
1998 • 7,572 citations
Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology
1997 • 2,870 citations
New use of BCG for recombinant vaccines
1991 • 1,463 citations
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
1996 • 1,088 citations
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine
1996 • 629 citations
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis
1995 • 580 citations
MEXILETINE FOR TREATMENT OF CHRONIC PAINFUL DIABETIC NEUROPATHY
1988 • 535 citations
Vaccination against tuberculosis by DNA injection
1996 • 513 citations
BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life.
1977 • 505 citations
A Mycobacterium tuberculosis operon encoding ESAT=6 and a novel low-molecular-mass culture filtrate protein (CFP-10)
1998 • 479 citations
Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG
1996 • 459 citations
Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis.
1995 • 438 citations
Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins
1994 • 431 citations
Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi
1996 • 368 citations
Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi
1992 • 208 citations
Recurrent Japanese encephalitis epidemics in West Bengal.
1980 • 142 citations
Two-Dimensional Electrophoresis for Analysis ofMycobacterium tuberculosisCulture Filtrate and Purification and Characterization of Six Novel Proteins
1998 • 129 citations
MPB70, a unique antigen of Mycobacterium bovis BCG.
1984 • 117 citations
La vaccination preventive contre la tuberculose par le "BCG"
1927 • 107 citations
Evidence for absence of the MPB64 gene in some substrains of Mycobacterium bovis BCG
1993 • 106 citations
DNA fingerprinting of Mycobacterium bovis strains by restriction fragment analysis and hybridization with insertion elements IS1081 and IS6110
1993 • 94 citations
Structure and function of a 40,000-molecular-weight protein antigen of Mycobacterium tuberculosis
1992 • 88 citations
Long-term complete remission inbladder carcinoma in situ with intravesical tice bacillus Calmette guerin
1991 • 85 citations
Protective vaccination against tuberculosis with special reference to BCG vaccination.
1948 • 83 citations
Use of gene probes based on the insertion sequence IS986 to differentiate between BCG vaccine strains
1992 • 81 citations
Cloning and B-cell-epitope mapping of MPT64 from Mycobacterium tuberculosis H37Rv
1994 • 77 citations
The stability and immunogenicity of a dispersed-grown freeze-dried pasteur BCG vaccine
1988 • 70 citations
Differential characteristics in vitro and in vivo of several substrains of BCG. IV. Immunizing effectiveness.
1956 • 67 citations
Changes in BCG strains
1983 • 65 citations
Differential characteristics in vitro and in vivo of several substrains of BCG. I. Multiplication and survival in vitro.
1956 • 64 citations
Potency of 10 BCG vaccines as evaluated by their influence on the bacillemic phase of experimental airborne tuberculosis in guinea-pigs
1979 • 63 citations
Tuberculin sensitivity in guinea-pigs after vaccination with varying doses of BCG of 12 different strains.
1976 • 62 citations
Antibody responses against Mycobacterium tuberculosis in 11 strains of inbred mice: novel monoclonal antibody specificities generated by fusions, using spleens from BALB.B10 and CBA/J mice
1988 • 58 citations
Adverse reactions in healthy and immunocompromised children under six years of age vaccinated with the Danish BCG vaccine, strain Copenhagen 1331: implications for the vaccination policy in Sweden
1993 • 57 citations
Mycolic Acid Patterns of Representatives of Mycobacterium bovis BCG
1984 • 55 citations
INTRADERMAL VACCINATIONS WITH B C G VIRUS
1928 • 51 citations
MPB 64 Possesses Tuberculosis‐Complex'‐Specific B‐ and T‐Cell Epitopes
1991 • 46 citations
Some evidence of the efficacy of mass BCG vaccination.
1965 • 43 citations
BCG Vaccination Against Tuberculosis
1957 • 42 citations
The protective effect in bank voles of some strains of BCG.
1970 • 39 citations
Genetic differences between BCG substrains
1995 • 39 citations
BCG Vaccine: tuberculosis—Cancer
1980 • 37 citations
History of BCG and its substrains.
1989 • 37 citations
Tuberculin sensitivity and skin lesions in children after vaccination with 11 different BCG strains.
1974 • 36 citations
BCG vaccine, tuberculosis--cancer
1980 • 36 citations
The virulence of some strains of BCG for golden hamsters.
1968 • 34 citations
BCG Vaccination in Denmark
1946 • 28 citations
Characterization of Purified Protein Derivative of Tuberculin by use of Monoclonal Antibodies: Isolation of a Delayed‐Type Hypersensitivity Reactive Component from M. tuberculosis Culture Filtrate
1994 • 27 citations
Biological Activity in Sensitized Guinea Pigs of MPB 70, a Protein Specific for Some Strains of Mycobacterium bovis BCG
1987 • 26 citations
The virulence of some strains of BCG for golden hamsters. Further studies.
1970 • 26 citations
MUTATION AND PATHOGENICITY EXPERIMENTS WITH B C G.
1931 • 18 citations
Differential transcription of the MPB70 genes in two major groups of Mycobacterium bovis BCG substrains
1995 • 18 citations
THE VIRULENCE OF VARIOUS STRAINS OF BCG DETERMINED ON THE GOLDEN HAMSTER.
1964 • 17 citations
Evaluation of BCG vaccines in children, the effect of strain and dose
1977 • 16 citations
The efficacy of BCG-vaccination; epidemic of tuberculosis in a State School, with an observation period of 12 years.
1956 • 16 citations
EFFECT OF VACCINATION WITH B C G ON CHILDREN FROM TUBERCULOUS FAMILIES
1933 • 14 citations
Variation in the duration of tuberculin skin sensitivity produced by two strains of BCG.
1949 • 14 citations
Effect of the method of preparation of Bacille Calmette‐Guérin (BCG) vaccine on the properties of four daughter strains
1987 • 14 citations
BCG vaccine in perspective.
1974 • 13 citations
The BCG vaccine.
1949 • 13 citations
Researches on Bacillus-Calmette-Guérin and Experimental Vaccination against Bovine Tuberculosis.
1928 • 11 citations
Effect of Calmette's BCG Vaccine on Experimental Animals
1929 • 10 citations
STUDIES ON BACILLUS CALMETTE-GUÉRIN (B.C.G.) AND VACCINATION AGAINST TUBERCULOSIS
1933 • 10 citations
BCG on Sauton's medium; effect of a long series of subcultures on the morphological and biological properties of BCG cultures.
1950 • 9 citations
Quantitative evaluation of the effectiveness of Connaught freeze-dried BCG vaccine in mice and in guineapigs.
1974 • 9 citations
Die Calmettesche Schutzimpfung und die Säuglingserkrankungen in Lübeck
1930 • 9 citations
Variations in the virulence of BCG.
1948 • 8 citations
BCG Vaccination in Western Europe1
2019 • 7 citations
B.C.G. Vaccination in Theory and Practice.
1950 • 7 citations
DEEP BROTH CULTURES OF B C G.
1931 • 3 citations
Die Schutzimpfung gegen Tuberkulose mit B.C.G. nach Calmette-Guérin
1930 • 3 citations
Effect of the method of preparation of Bacille Calmette-Guérin (BCG) vaccine on the properties of four daughter strains
1987 • 1 citations
Deleted Work
1955 • 0 citations