BCG Against Covid-19 for Prevention and Amelioration of Severity Trial (BAC to the PAST)

NCT04534803

PHASE3INTERVENTIONAL

Harvard Medical School (HMS and HSDM)

0

Started 2021-09 · Completed 2022-07

Status: Withdrawn (as of 12-23-2025)

Conditions

Covid19

Interventions

DRUG: BCG Vaccine OTHER: Placebo

Linked Papers (from SciSciNet-V2)

Total Papers95

Background

39

Result

0

Derived

0

Unknown

56

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The purpose of this study is to assess the efficacy of Bacille Calmette-Guérin (BCG) vaccination compared to placebo in reducing severe Covid-19 disease among elderly residents of skilled nursing facilities. The investigators hypothesize that BCG vaccination can reduce severity of Covid-19 disease. Patients who are residents of participating long-term care facilities (LTCFs), with the ability to understand and cooperate with study procedures, who agree to participate in the study will be randomly assigned to receive BCG vaccination or a placebo. Participants will be followed for up to twelve months to assess severity of Covid-19 outcomes.

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Background Papers78

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

9,290 citations

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

9,290 citations

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

8,517 citations

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

8,517 citations

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

8,060 citations

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

8,060 citations

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

4,912 citations

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

4,912 citations

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

3,624 citations

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

3,624 citations

Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

2,264 citations

Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

2,264 citations

Defining trained immunity and its role in health and disease

1,780 citations

Defining trained immunity and its role in health and disease

1,780 citations

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

1,414 citations

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

1,414 citations

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Acute pulmonary embolism and COVID-19 pneumonia: a random association?

Acute pulmonary embolism and COVID-19 pneumonia: a random association?

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

Genome plasticity of BCG and impact on vaccine efficacy

Genome plasticity of BCG and impact on vaccine efficacy

Clinical Features and Short-term Outcomes of 102 Patients with Coronavirus Disease 2019 in Wuhan, China

Clinical Features and Short-term Outcomes of 102 Patients with Coronavirus Disease 2019 in Wuhan, China

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

Preventive Vaccination against Tuberculosis with BCG

Preventive Vaccination against Tuberculosis with BCG

Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19

Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19

EFFECTS OF CELLULAR CONSTITUENTS OF MYCOBACTERIA ON THE RESISTANCE OF MICE TO HETEROLOGOUS INFECTIONS

EFFECTS OF CELLULAR CONSTITUENTS OF MYCOBACTERIA ON THE RESISTANCE OF MICE TO HETEROLOGOUS INFECTIONS

Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial

Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross-immunity on challege in vivo.

Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial

Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross-immunity on challege in vivo.

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

Storm, typhoon, cyclone or hurricane in patients with COVID-19? Beware of the same storm that has a different origin

Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations

Storm, typhoon, cyclone or hurricane in patients with COVID-19? Beware of the same storm that has a different origin

Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice

Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice

Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis

Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis

Effect of treatment with BCG on the course of visceral leishmaniasis in BALB/c mice

Effect of treatment with BCG on the course of visceral leishmaniasis in BALB/c mice

BCG: who were Calmette and Guerin?

BCG: who were Calmette and Guerin?

Molecular Analysis of Non-Specific Protection against Murine Malaria Induced by BCG Vaccination

Molecular Analysis of Non-Specific Protection against Murine Malaria Induced by BCG Vaccination

Comparative Tuberculosis (TB) Prevention Effectiveness in Children of Bacillus Calmette-Guérin (BCG) Vaccines from Different Sources, Kazakhstan

Comparative Tuberculosis (TB) Prevention Effectiveness in Children of Bacillus Calmette-Guérin (BCG) Vaccines from Different Sources, Kazakhstan

Risk factors for community-acquired pneumonia among adults in Kenya: a case–control study

Risk factors for community-acquired pneumonia among adults in Kenya: a case–control study

Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults

Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults

Herpesvirus hominis Type 2 Infections in Rabbits: Effect of Prior Immunization with Attenuated Mycobacterium bovis (BCG) Cells

Herpesvirus hominis Type 2 Infections in Rabbits: Effect of Prior Immunization with Attenuated Mycobacterium bovis (BCG) Cells

Effect of Mycobacterium tuberculosis BCG infection on the resistance of mice to ectromelia virus infection: participation of interferon in enhanced resistance

Effect of Mycobacterium tuberculosis BCG infection on the resistance of mice to ectromelia virus infection: participation of interferon in enhanced resistance

Mechanisms of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection

Mechanisms of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection

Ineffectiveness and toxicity of BCG vaccine for the prevention of recurrent genital herpes

Ineffectiveness and toxicity of BCG vaccine for the prevention of recurrent genital herpes

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers56

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

4,303 citations

Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients

1,589 citations

Variation in protection by BCG: implications of and for heterologous immunity

1,347 citations

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

1,346 citations

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

Covid-19 and Post Intensive Care Syndrome: A Call for Action

Protection of mice against Babesia, and Plasmodium with BCG

A historical and molecular phylogeny of BCG strains

Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau: a beneficial effect of BCG vaccination for girls

BCG vaccination scar associated with better childhood survival in Guinea-Bissau

Second IUATLD study on complications induced by intradermal BCG-vaccination.

Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis

The efficacy of Bacillus Calmette-Guerin vaccinations for the prevention of acute upper respiratory tract infection in the elderly.

Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree

The Role of BCG/PPD‐Activated Macrophages in Resistance against Systemic Candidiasis in Mice

BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy

The Effect of Bacille Calmette‐Guérin Vaccine Strain and Route of Administration on Induced Immune Responses in Vaccinated Infants

The Influence of Bacille Calmette-Guérin Vaccine Strain on the Immune Response against Tuberculosis

The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection.

Nonspecific Protection of Mice against Influenza Virus Infection by Local or Systemic Immunization with Bacille Calmette-Guerin

Acute Lower Respiratory Infection Among Bacille Calmette-Guérin (BCG)–Vaccinated Children

Immune Responses Stimulated by Percutaneous and Intradermal Bacille Calmette-Guerin

Effects of Immunostimulants on Resistance of Newborn Mice to Herpes Simplex Type 2 Infection

Nonspecific Effects of Vaccines and the Reduction of Mortality in Children

Treatment of Common and Plane Warts in Children with Topical Viable Bacillus Calmette‐Guerin

Differential productions of lipid virulence factors among BCG vaccine strains and implications on BCG safety

Nonspecific effect of BCG vaccination at birth on early childhood infections: a randomized, clinical multicenter trial

Fatores de risco para morte por pneumonia em menores de um ano em uma região metropolitana do sudeste do Brasil: um estudo tipo caso-controle

Clinical Reactogenicity of Intradermal Bacille Calmette‐Guérin Vaccination

Increased resistance to virus infections of mice inoculated with BCG (Bacillus calmette-guérin).

Recurrent herpes genitalis. Treatment with Mycobacterium bovis (BCG).

Conditions for Bacille Calmette-Guerin-Induced Resistance to Infection with Schistosoma mansoni in Mice

Early Vaccination With Bacille Calmette-Guérin-Denmark or BCG-Japan Versus BCG-Russia to Healthy Newborns in Guinea-Bissau: A Randomized Controlled Trial

Effect of BCG Infection on Leukemia and Polyoma in Mice and Hamsters.

Bacillus Calmette–Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice

Immunotherapy in viral warts with intradermal Bacillus Calmette–Guerin vaccine versus intradermal tuberculin purified protein derivative: A double-blind, randomized controlled trial comparing effectiveness and safety in a tertiary care center in Eastern India

A Vaccination Procedure Against Trypanosoma Cruzi Infection in Mice by Nonspecific Immunization

Bacille Calmette-Guerin Immunization in Normal Healthy Adults

BCG vaccine for immunotherapy in warts: is it really safe in a tuberculosis endemic area?

[Severe adverse reactions after vaccination with Japanese BCG vaccine: a review].

The effect of BCG on the course of experimental Chagas' disease in mice

[Nonspecific immune stimulation with BCG in Herpes simplex recidivans. Follow-up 5 to 10 years after BCG vaccination].

Bacillus Calmette-Guérin Confers Neuroprotection in a Murine Model of Japanese Encephalitis

Immunotherapy of Friend Disease in Mice Employing Viable BCG Vaccine

Non-specific effects of BCG vaccination on morbidity among children in Greenland: a population-based cohort study

Studies of the effects of Bacillus Calmette-Guérin on Moloney sarcoma virus-induced tumors in normal and immunosuppressed mice.

Dried BCG vaccine.

Comparison of the safety and immunogenicity of the lyophilized Mérieux seed and the World Health Organization working reference BCG vaccines in school-aged children in Senegal

Lack of BCG vaccination and other risk factors for bacteraemia in severely malnourished children with pneumonia

Simulated Surgical Wound Infection in Mice

The effect of BCG-vaccination on vaccinia virus infections in mice

Early-sharedMycobacterium bovisbacillus Calmette-Guérin sub-strains induce Th1 cytokine productionin vivo