CYP2D6 , SULT1A1 and UGT2B17 Copy Number Variation: Quantitative Detection by Multiplex PCR

Modulation of Non-Templated Nucleotide Addition by Taq DNA Polymerase: Primer Modifications that Facilitate Genotyping

1996 • 1,264 citations

The evolution of gene duplications: classifying and distinguishing between models

2010 • 1,223 citations

Mechanisms of change in gene copy number

2009 • 1,212 citations

Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects

2007 • 1,122 citations

The Cytochrome P450 Homepage

2009 • 932 citations

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

2004 • 792 citations

Common deletion polymorphisms in the human genome

2005 • 722 citations

The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype

2007 • 722 citations

Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

2004 • 708 citations

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

2006 • 666 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Enzymology of human cytosolic sulfotransferases

1997 • 594 citations

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

2008 • 566 citations

Evolution of the P450 gene superfamily:

1990 • 508 citations

Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication

2006 • 426 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

1996 • 373 citations

Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study

2008 • 299 citations

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1998 • 284 citations

Genome-wide Copy-Number-Variation Study Identified a Susceptibility Gene, UGT2B17, for Osteoporosis

2008 • 199 citations

Genomic copy number variation, human health, and disease

2009 • 192 citations

Gene copy number variation spanning 60 million years of human and primate evolution

2007 • 174 citations

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR

2003 • 154 citations

Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics

1998 • 150 citations

Cytochrome P4502D6 (CYP2D6) Gene Locus Heterogeneity: Characterization of Gene Duplication Events

2007 • 147 citations

Cytochrome P450 2D6

2009 • 129 citations

UGT genomic diversity: beyond gene duplication

2009 • 129 citations

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6

1992 • 123 citations

Human SULT1A1 gene: copy number differences and functional implications

2006 • 106 citations

Characterization of 107 Genomic DNA Reference Materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1

2010 • 101 citations

Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics

2003 • 93 citations

Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease

2009 • 90 citations

CYP2D6*36GENE ARRANGEMENTS WITHIN THECYP2D6LOCUS: ASSOCIATION OFCYP2D6*36WITH POOR METABOLIZER STATUS

2006 • 87 citations

CYP2D6 Genotyping for Functional-Gene Dosage Analysis by Allele Copy Number Detection

2009 • 81 citations

Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate

2007 • 74 citations

Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system

2010 • 72 citations

Determination of Cytochrome P450 2D6 (CYP2D6) Gene Copy Number by Real‐Time Quantitative PCR

2005 • 70 citations

Determination of CYP2D6 Gene Copy Number by Pyrosequencing

2005 • 67 citations

n/a not/available

2001 • 64 citations

The UGT2B17 gene deletion polymorphism and risk of prostate cancer

2007 • 61 citations

CYP2D7–2D6 Hybrid Tandems: Identification of Novel CYP2D6 Duplication Arrangements and Implications for Phenotype Prediction

2009 • 60 citations

Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants

2010 • 57 citations

CYP2D6: novel genomic structures and alleles

2009 • 56 citations

CCL3L1 and HIV/AIDS susceptibility

2009 • 54 citations

Multiplex Paralogue Ratio Tests for accurate measurement of multiallelic CNVs

2008 • 47 citations

Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays

2010 • 40 citations

Sulphation of o‐desmethylnaproxen and related compounds by human cytosolic sulfotransferases

2005 • 29 citations

Determination of SMN1/SMN2 Gene Dosage by a Quantitative Genotyping Platform Combining Capillary Electrophoresis and MALDI-TOF Mass Spectrometry

2006 • 25 citations

Very important pharmacogene summary: sulfotransferase 1A1

2009 • 24 citations

Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip

2010 • 24 citations

Combination of multiplex PCR and DHPLC-based strategy for CYP2D6 genotyping scheme in Thais

2011 • 23 citations

Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer

2010 • 22 citations

TaqMan real-time PCR quantification strategy of CYP2D6 gene copy number for the LightCycler 2.0

2009 • 20 citations

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis

2009 • 14 citations

Determination of genomic copy number with quantitative microsphere hybridization

2006 • 8 citations

UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology

2010 • 4 citations

The presence of the UGT2B17 gene is associated with lung cancer in male Chinese Han smokers

2010 • 2 citations