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Atomoxetine PBPK-PD Clinical Study
NCT03154359
NULLOBSERVATIONAL
Children's Mercy Hospital Kansas City
51 participants
Started 2017-12-12 · Completed 2022-06-16
Status: Completed (as of 12-23-2025)
Conditions
ADHD
Interventions
Linked Papers (from SciSciNet-V2)
Total Papers10
Background
3Result
0Derived
0Unknown
7Total Citations Per Year
Brief Summary
The primary aims of this study focus on characterizing the relationship between atomoxetine exposure and clinical outcomes, as assessed by standardized measures. We will also simultaneously monitor side effect of atomoxetine, another measure of clinical outcomes, and categorize study participants on their ability to tolerate atomoxetine.
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Background Papers6
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
2006
150 citations
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
2006
150 citations
CYP2D7–2D6 Hybrid Tandems: Identification of Novel CYP2D6 Duplication Arrangements and Implications for Phenotype Prediction
2009
60 citations
CYP2D7–2D6 Hybrid Tandems: Identification of Novel CYP2D6 Duplication Arrangements and Implications for Phenotype Prediction
2009
60 citations
Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants
2010
57 citations
Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants
2010
57 citations
Result Papers0
No result papers linked
Derived Papers0
No derived papers linked
Unknown Papers7
The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype
2007
722 citations
Complexities ofCYP2D6gene analysis and interpretation
2013
207 citations
CYP2D6 and Clinical Response to Atomoxetine in Children and Adolescents With ADHD
2007
149 citations
Cytochrome P4502D6 (CYP2D6) Gene Locus Heterogeneity: Characterization of Gene Duplication Events
2007
147 citations
Clinical Responses to Atomoxetine in Attention-Deficit/Hyperactivity Disorder: The Integrated Data Exploratory Analysis (IDEA) Study
2009
84 citations
Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
2006
76 citations
CYP2D6 , SULT1A1 and UGT2B17 Copy Number Variation: Quantitative Detection by Multiplex PCR
2011
69 citations