Energy functions for protein design

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

DREIDING: a generic force field for molecular simulations

1990 • 5,956 citations

A new force field for molecular mechanical simulation of nucleic acids and proteins

1984 • 4,553 citations

Dominant forces in protein folding

1990 • 3,682 citations

Tertiary templates for proteins

1987 • 1,485 citations

De Novo Protein Design: Fully Automated Sequence Selection

1997 • 1,129 citations

DENATURED STATES OF PROTEINS

1991 • 870 citations

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides.

1987 • 737 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

Atomic solvation parameters applied to molecular dynamics of proteins in solution

1992 • 527 citations

High-Resolution Protein Design with Backbone Freedom

1998 • 457 citations

Design, structure and stability of a hyperthermophilic protein variant

1998 • 348 citations

The stability of salt bridges at high temperatures: implications for hyperthermophilic proteins 1 1Edited by B. Honig

1998 • 304 citations

De novo design of the hydrophobic cores of proteins

1995 • 301 citations

Protein design automation

1996 • 291 citations

Probing the role of packing specificity in protein design

1997 • 252 citations

A Buried Polar Interaction Imparts Structural Uniqueness in a Designed Heterodimeric Coiled Coil

1998 • 250 citations

Automated design of the surface positions of protein helices

1997 • 233 citations

Computational protein design

1999 • 193 citations

De novo design of the hydrophobic core of ubiquitin

1997 • 181 citations

Repacking protein cores with backbone freedom: structure prediction for coiled coils.

1995 • 149 citations

Pairwise calculation of protein solvent-accessible surface areas

1998 • 143 citations

Optimal sequence selection in proteins of known structure by simulated evolution.

1994 • 130 citations

Molecular dynamics simulations of the hyperthermophilic protein sac7d from Sulfolobus acidocaldarius : contribution of salt bridges to thermostability 1 1Edited by B. Honig

1999 • 102 citations

Surface salt bridges stabilize the GCN4 leucine zipper

1998 • 92 citations

Coupling backbone flexibility and amino acid sequence selection in protein design

1997 • 91 citations

Effects of salt bridges on protein structure and design

1998 • 86 citations

Computer search algorithms in protein modification and design

1998 • 84 citations

A Designed Buried Salt Bridge in a Heterodimeric Coiled Coil

1997 • 71 citations

Ade NovoDesigned Protein with Properties That Characterize Natural Hyperthermophilic Proteins

1997 • 43 citations

Protien side-chain conformational entropy derived from fusion data-comparison with other empirical scales

1994 • 35 citations

Designing the hydrophobic core of Thermus flavus malate dehydrogenase based on side-chain packing

1998 • 29 citations