Electrostatic Screening of Charge and Dipole Interactions with the Helix Backbone

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

Theory of Solutions of Molecules Containing Widely Separated Charges with Special Application to Zwitterions

1934 • 1,491 citations

pKa's of ionizable groups in proteins: atomic detail from a continuum electrostatic model

1990 • 1,056 citations

The α-helix dipole and the properties of proteins

1978 • 985 citations

Calculation of the electric potential in the active site cleft due to α-helix dipoles

1982 • 931 citations

Theory of Protein Titration Curves. I. General Equations for Impenetrable Spheres

1957 • 798 citations

Unusually stable helix formation in short alanine-based peptides.

1989 • 752 citations

Evaluation of a new broadband decoupling sequence: WALTZ-16

1983 • 739 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

The Electrostatic Influence of Substituents on the Dissociation Constants of Organic Acids. I

1938 • 417 citations

Capping and α-helix stability

1989 • 363 citations

Large differences in the helix propensities of alanine and glycine

1991 • 307 citations

Enhanced protein thermostability from designed mutations that interact with α-helix dipoles

1988 • 290 citations

Dipoles of the α-helix and β-sheet: their role in protein folding

1981 • 275 citations

Internal Stark Effect Measurement of the Electric Field at the Amino Terminus of an α Helix

1992 • 259 citations

Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

1988 • 229 citations

Experimental evaluation of the effective dielectric constant of proteins

1980 • 223 citations

Short alanine-based peptides may form 310-helices and not α-helices in aqueous solution

1992 • 205 citations

Secondary structure of the α-amylase polypeptide inhibitor Tendamistat from Streptomyces tendae determined in solution by 1H nuclear magnetic resonance

1985 • 200 citations

Designing substrate specificity by protein engineering of electrostatic interactions.

1987 • 199 citations

Dipoles localized at helix termini of proteins stabilize charges.

1991 • 170 citations

The Electrostatic Influence of Substituents on the Dissociation Constants of Organic Acids. II

1938 • 170 citations

Tailoring the pH dependence of enzyme catalysis using protein engineering

1985 • 168 citations

Analysis of the interaction between charged side chains and the .alpha.-helix dipole using designed thermostable mutants of phage T4 lysozyme

1991 • 164 citations

Further studies of the helix dipole model: Effects of a free α‐NH₃⁺ or α‐COO⁻ group on helix stability

1989 • 145 citations

A neutral, water-soluble, .alpha.-helical peptide: the effect of ionic strength on the helix-coil equilibrium

1991 • 144 citations

Histidine residues at the N- and C-termini of .alpha.-helixes: perturbed pKas and protein stability

1992 • 122 citations

Kinetics of amide proton exchange in helical peptides of varying chain lengths. Interpretation by the Lifson-Roig equation

1992 • 110 citations

Electrostatic interactions in wild-type and mutant recombinant human myoglobins

1989 • 94 citations

Electrostatic forces in two lysozymes: Calculations and measurements of histidine pKa values

1992 • 78 citations

Analysis of asymmetry in the distribution of helical residues in peptides by proton nuclear magnetic resonance

1991 • 57 citations

Dissociation constants of bicyclo[2.2.2]oct-2-ene-1-carboxylic acids, dibenzobicyclo[2.2.2]octa-2,5-diene-1-carboxylic acids, and cubanecarboxylic acids

1967 • 52 citations

High-frequency dielectric relaxation of water bound to hydrophilic silica gels

1989 • 48 citations

Influence of Electrolyte on effective Dielectric constants in Enzymes, proteins and other molecules

1956 • 39 citations

Transmission of substituent effects. Generalization of the ellipsoidal cavity field effect model

1976 • 37 citations

Position-dependent local motions in spin-labeled analogs of a short .alpha.-helical peptide determined by electron spin resonance

1991 • 35 citations