Genetic variability and clinical efficacy of morphine

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

2003 • 1,750 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

COMT val ¹⁵⁸ met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

2003 • 1,103 citations

Inheritance and Drug Response

2003 • 1,028 citations

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis

1996 • 622 citations

Pharmacokinetics, Pharmacodynamics, and Rational Opioid Selection

1991 • 571 citations

Human UGT2B7 catalyzes morphine glucuronidation.

1997 • 416 citations

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

1989 • 373 citations

The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

2004 • 370 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

1996 • 308 citations

Sequence variability and candidate gene analysis in complex disease: association of micro opioid receptor gene variation with substance dependence

2000 • 291 citations

Clinical Pharmacokinetics of Morphine

1991 • 280 citations

Opiate-induced Analgesia Is Increased and Prolonged in Mice Lacking P-glycoprotein

2000 • 270 citations

A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling

2001 • 243 citations

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

2003 • 222 citations

Gender differences in drug effects: implications for anesthesiologists

2003 • 215 citations

Incomplete cross tolerance and multiple mu opioid peptide receptors

2001 • 208 citations

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

2002 • 208 citations

A pharmacogenetic study of uridine diphosphate–glucuronosyltransferase 2B7 in patients receiving morphine

2003 • 174 citations

Oral morphine in cancer pain: influences on morphine and metabolite concentration

1990 • 163 citations

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

2003 • 160 citations

A novel functional polymorphism in the uridine diphosphate–glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

2004 • 147 citations

Does the A118G Polymorphism at the μ-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity?

2002 • 144 citations

The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function

1992 • 135 citations

STUDIES ON MORPHINE DISPOSITION: INFLUENCE OF RENAL FAILURE ON THE KINETICS OF MORPHINE AND ITS METABOLITES

1989 • 129 citations

Pharmacokinetics and clinical efficacy of oral morphine solution and controlled-release morphine tablets in cancer patients

1989 • 114 citations

Blood‐brain barrier transport and brain distribution of morphine‐6‐glucuronide in relation to the antinociceptive effect in rats – pharmacokinetic/pharmacodynamic modelling

2001 • 103 citations

Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X

2003 • 101 citations

Morphine antinociception is enhanced in mdr1a gene-deficient mice.

2000 • 99 citations

Ethnic differences in response to morphine

1993 • 98 citations

Is disease progression the major factor in morphine ‘tolerance’ in cancer pain treatment?

1993 • 96 citations

Ethnicity influences morphine pharmacokinetics and pharmacodynamics

2001 • 90 citations

Use of the erythromycin breath test for in vivo assessments of cytochrome P4503A activity and dosage individualization

2001 • 89 citations

The minimally effective concentration of adrenaline in a low‐concentration thoracic epidural analgesic infusion of bupivacaine, fentanyl and adrenaline after major surgery A randomized, double‐blind, dose‐finding study.

2003 • 87 citations

Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

2000 • 87 citations

Effect of P‐glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

2000 • 80 citations

Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine

2003 • 64 citations

Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients

2003 • 60 citations

Increased blood–brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis

2001 • 49 citations

Hepatocyte Nuclear Factor-1α Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

2002 • 44 citations

Altered brain exposure of morphine in experimental meningitis studied with microdialysis

2004 • 41 citations

Genetic analysis of the murine � opioid receptor: increased complexity of Oprm gene splicing

2004 • 37 citations

The genetics of pain: Progress in pain research and management

2006 • 10 citations