Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer’s disease

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

The cholinergic hypothesis of Alzheimer's disease: a review of progress

1999 • 2,013 citations

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease

1998 • 1,575 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Nicotinic acetylcholine involvement in cognitive function in animals

1998 • 689 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

1992 • 465 citations

Transmitter leakage from motor nerve endings

1977 • 443 citations

Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons

1997 • 443 citations

Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function.

1997 • 431 citations

Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology

1995 • 385 citations

Cholinesterase Inhibitors in the Treatment of Alzheimer??s Disease

1998 • 369 citations

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

1986 • 360 citations

Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease

1996 • 356 citations

Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1999 • 353 citations

Choline and Selective Antagonists Identify Two Subtypes of Nicotinic Acetylcholine Receptors that Modulate GABA Release from CA1 Interneurons in Rat Hippocampal Slices

1999 • 334 citations

Intravenous nicotine in Alzheimer's disease: a pilot study

1988 • 312 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability

1995 • 264 citations

Nicotinic Receptor Function in Schizophrenia

1996 • 261 citations

Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks

2000 • 251 citations

Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1994 • 240 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.

1996 • 222 citations

Kinetic Analysis of Regional (S)(-)11C-Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography

1995 • 211 citations

Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety

1995 • 198 citations

α4 but Not α3 and α7 Nicotinic Acetylcholine Receptor Subunits Are Lost from the Temporal Cortex in Alzheimer's Disease

1999 • 197 citations

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

1998 • 192 citations

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

1997 • 184 citations

Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

1999 • 169 citations

Potentiation and Inhibition of Neuronal Nicotinic Receptors by Atropine: Competitive and Noncompetitive Effects

1997 • 157 citations

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated‐tau protein

1999 • 155 citations

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

1991 • 149 citations

Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains

1995 • 148 citations

Clinical Diagnosis and Management of Alzheimer's Disease

2006 • 145 citations

Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior

1994 • 135 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

1995 • 117 citations

Cholinergic underactivity in human memory disorders

1978 • 104 citations

Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.

1994 • 103 citations

Nicotinic receptor: an allosteric protein specialized for intercellular communication

1995 • 93 citations

New approach to drug therapy in Alzheimer's dementia Alfred Maelicke and Edson X. Albuquerque

1996 • 92 citations

Sustained Nicotine Exposure Differentially Affects α3β2 and α4β2 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes

1996 • 84 citations

Photoaffinity labeling of Torpedo acetylcholine receptor by physostigmine

1993 • 79 citations

A 24-week randomized trial of controlled-release physostigmine in patients with Alzheimer’s disease

1999 • 73 citations

Kinetic Properties and Regulation of GABAA Receptor Channels

1992 • 69 citations

Ligand Binding and Activation of Rat Nicotinic α4β2 Receptors Stably Expressed in HEK293 Cells

1999 • 67 citations

NBD-5-acylcholine: fluorescent analog of acetylcholine and agonist at the neuromuscular junction.

1979 • 58 citations

Biochemical Aspects of Cholinergic Excitation

1984 • 58 citations

The hypothesis of an ambient level of acetylcholine in the central nervous system

1998 • 56 citations

Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide.

1994 • 55 citations

Presynaptic Muscarinic Receptors in the Central Nervous System^a

1990 • 54 citations

Do seizures cause neuronal damage? A MRI study in newly diagnosed, and chronic epilepsy

1994 • 50 citations

CNS Nicotinic Receptors

1994 • 48 citations

A Novel Agonist Binding Site on Nicotinic Acetylcholine Receptors

1993 • 44 citations

Effects of a novel cholinergic ion channel agonist SIB-1765F on locomotor activity in rats.

1997 • 43 citations

Enhancement of glycine release from human brain cortex synaptosomes by acetylcholine acting at M4 muscarinic receptors.

1993 • 31 citations

Allosteric modulation of neuronal nicotinic acetylcholine receptors

1998 • 31 citations

Modulatory control by non-competitive agonists of nicotinic cholinergic neurotransmission in the central nervous system

1995 • 28 citations

Chapter 9 Nicotinic acetylcholine receptors on hippocampal neurons: cell compartment-specific expression and modulatory control of channel activity

1996 • 27 citations

Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex

1996 • 23 citations

Mapping of a Binding Site for ATP within the Extracellular Region of the Torpedo Nicotinic Acetylcholine Receptor β-Subunit

1997 • 11 citations

Clinical diagnosis and management of Alzheimer's disease

1996 • 11 citations

Nicotine: not just for cigarettes anymore

1999 • 8 citations