Kinetic Properties and Regulation of GABAA Receptor Channels

Single-Channel Recording

1995 • 2,565 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

The effect of subunit composition of rat brain GABAA receptors on channel function

1990 • 592 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

Functional properties of recombinant rat GABAA receptors depend upon subunit composition

1990 • 557 citations

The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

1995 • 549 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

1991 • 426 citations

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA

1983 • 402 citations

Differential regulation of γ‐aminobutyric acid receptor channels by diazepam and phenobarbital

1989 • 331 citations

Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.

1990 • 328 citations

Molecular biology of the GABAA receptor: the receptor/channel superfamily

1987 • 303 citations

Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures

1977 • 280 citations

Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones

1978 • 276 citations

Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.

1989 • 266 citations

Modulation of the GABA _A receptor by progesterone metabolites

1987 • 245 citations

Neurosteroid regulation of GABAA receptor single‐channel kinetic properties of mouse spinal cord neurons in culture.

1992 • 241 citations

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

1989 • 225 citations

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

1989 • 216 citations

Activation of ion channels in the frog end‐plate by high concentrations of acetylcholine.

1988 • 214 citations

Modulation of GABA_A receptor activity by alphaxalone

1987 • 196 citations

Specific antagonism of GABA‐mediated postsynaptic inhibition in cultured mammalian spinal cord neurons

1978 • 191 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Potentiation of gamma‐aminobutyric‐acid‐activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.

1987 • 169 citations

The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

1983 • 167 citations

Diazepam enhancement of low affinity GABA binding to rat brain membranes

1982 • 166 citations

Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: A common mode of anticonvulsant action

1979 • 159 citations

Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in xenopus oocytes

1988 • 130 citations

Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neurons

1979 • 108 citations

Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neurons

1982 • 105 citations

Anticonvulsant and anesthetic barbiturates

1979 • 104 citations

Gating scheme for single GABA-activated Cl- channels determined from stability plots, dwell-time distributions, and adjacent-interval durations

1989 • 101 citations

Patch-clamp measurements of elementary chloride currents activated by the putative inhibitory transmitter GABA and glycine in mammalian spinal neurons.

1983 • 92 citations

Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

1990 • 92 citations

Actions of benzodiazepine and beta-carboline derivatives on gamma-aminobutyric acid-activated Cl- channels recorded from membrane patches of neonatal rat cortical neurons in culture.

1987 • 87 citations

Pentobarbital and picrotoxin have reciprocal actions on single GABAA receptor channels

1989 • 74 citations

Neurotoxicity of Intravenously Administered Penicillin G

1971 • 58 citations

Kinetics of open channel block by penicillin of single GABAA receptor channels from mouse spinal cord neurones in culture.

1992 • 58 citations

Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties

1990 • 56 citations

Convulsant doses of penicillin shorten the lifetime of GABA‐induced channels in cultured central neurones

1986 • 38 citations

GABA and muscimol open ion channels of different lifetimes on cultured mouse spinal cord cells

1981 • 15 citations

Deleted Work

1955 • 0 citations