Protein phylogenies provide evidence of a radical discontinuity between arthropod and vertebrate immune systems

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP

1985 • 39,646 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

CLUSTAL V: improved software for multiple sequence alignment

1992 • 2,421 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Peptide Antibiotics and Their Role in Innate Immunity

1995 • 1,602 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

What's new in lysozyme research?

1984 • 911 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.

1993 • 641 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Immune reactions in Drosophila and other insects: a model for innate immunity

1993 • 417 citations

Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages

1995 • 397 citations

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

1990 • 311 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

1986 • 297 citations

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.

1994 • 295 citations

Accelerated evolution in the reactive centre regions of serine protease inhibitors

1987 • 293 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Hemolin: an Insect-Immune Protein Belonging to the Immunoglobulin Superfamily

1990 • 247 citations

Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase.

1995 • 244 citations

Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster.

1995 • 243 citations

cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.

1987 • 235 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit.

1978 • 223 citations

Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

1990 • 221 citations

T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family

1996 • 212 citations

Sequence of a cDNA and expression of the gene encoding epidermal and gut chitinases of Manduca sexta

1993 • 209 citations

Limulin: a C-reactive protein from Limulus polyphemus.

1981 • 204 citations

The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract

1994 • 199 citations

Immunity and the Invertebrates

1996 • 193 citations

Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains.

1991 • 177 citations

The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo

1989 • 175 citations

Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system

1995 • 160 citations

A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease

1986 • 148 citations

Signals from the IL-1 Receptor Homolog, Toll, Can Activate an Immune Response in a Drosophila Hemocyte Cell Line

1995 • 143 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

1994 • 141 citations

malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour.

1995 • 140 citations

Cloning of the mRNA for the protein that crosslinks to the egg peptide speract.

1989 • 127 citations

Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.

1992 • 127 citations

Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene

1989 • 126 citations

Are Invertebrates Capable of Anticipatory Immune Responses?

1989 • 120 citations

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

1987 • 119 citations

Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.

1988 • 118 citations

IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice.

1992 • 114 citations

Bacteria‐induced protein P4 (hemolin) from Manduca sexta: A member of the immunoglobulin superfamily which can inhibit hemocyte aggregation

1991 • 111 citations

Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.

1985 • 100 citations

An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages

1995 • 93 citations

The sperm acrosomal matrix contains a novel member of the pentaxin family of calcium-dependent binding proteins.

1994 • 84 citations

Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)

1996 • 79 citations

Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.

1988 • 79 citations

Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.

1991 • 69 citations

Molecular evolution of the vertebrate immune system.

1994 • 63 citations

Sequences of Two Highly Divergent Canine Type c Lysozymes: Implications for the Evolutionary Origins of the Lysozyme/α-Lactalbumin Superfamily

1994 • 61 citations

The cytokine factsbook

1994 • 60 citations

An estrogen-dependent secretory protein, which shares identity with chitinases, is expressed in a temporally and regionally specific manner in the sheep oviduct at the time of fertilization and embryo development.

1995 • 59 citations

Identification of a novel member of the pentrax in family inXenopus laevis

1993 • 57 citations

Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.

1988 • 54 citations

Molecular Cloning of Bomapin (Protease Inhibitor 10), a Novel Human Serpin That Is Expressed Specifically in the Bone Marrow

1995 • 51 citations

The macrophage-specific membrane protein Nramp controlling natural resistance to infections in mice has homologues expressed in the root system of plants

1995 • 48 citations

The Adhesion Molecule FactsBook

2000 • 45 citations

Gene Structure, Chromosomal Localization, and Expression of the Murine Homologue of Human Proteinase Inhibitor 6 (PI-6) Suggests Divergence of PI-6 from the Ovalbumin Serpins

1995 • 42 citations

Interspecific comparisons reveal conserved features of the Drosophila Toll protein

1994 • 36 citations

A cDNA clone from the sea lamprey Petromyzon marinus coding for a scavenger receptor Cys-rich (SRCR) domain protein

1995 • 35 citations

Innate immunity: Mast cells in the front line

1996 • 16 citations

Pathways of macrophage activation and innate immunity

1994 • 16 citations

Serine Protease Inhibitors from the Serpin Gene Family in Manduca sexta and Drosophila melanogaster

1990 • 12 citations

Inducible Humoral Immune Defense Responses in Insects

1996 • 10 citations

C-reactive Protein (CRP) in Animals : Its Chemical Properties and Biological Functions

1992 • 8 citations