Accelerated evolution in the reactive centre regions of serine protease inhibitors

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Evolutionary Genetics

1987 • 15,266 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Evolution of genes and proteins.

1983 • 1,224 citations

A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.

1985 • 1,064 citations

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.

1980 • 767 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

α1-Antitrypsin and the serpins: variation and countervariation

1985 • 384 citations

X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.

1986 • 272 citations

Synthesis in yeast of a functional oxidation-resistant mutant of human α1-antitrypsin

1984 • 209 citations

Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.

1984 • 179 citations

Human α-1-antichymotrypsin: interaction with chymotrypsin-like proteinases

1978 • 174 citations

Elastases and Elastin Degradation

1982 • 164 citations

Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni.

1985 • 152 citations

Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells.

1986 • 137 citations

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions

1984 • 135 citations

Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis

1985 • 125 citations

Evolution of DNA Sequences

1985 • 124 citations

Developmentally regulated mRNAs in mouse liver.

1982 • 79 citations

Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin.

1983 • 70 citations

A Genetic Locus Closely Linked to a Protease Inhibitor Gene Complex Controls the Level of Multiple RNA Transcripts

1985 • 62 citations

A genetic locus closely linked to a protease inhibitor gene complex controls the level of multiple RNA transcripts.

1985 • 40 citations

Inhibitory Spectrum of Mouse Contrapsin and α-1-Antitrypsin against Mouse Serine Proteases1

1983 • 35 citations

Interaction between human serum α1-antichymotrypsin and human leukocyte cathepsin G complex formation and production of a modified inhibitor

1982 • 26 citations